Structural insights into impact of Y134F mutation and discovery of novel fungicidal compounds against CYP51 in Puccinia triticina
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DOI: 10.1002/jcb.26422
Abstract: Sterol 14α‐Demethylase Cytochrome P450 (CYP51) protein involved in ergosterol biosynthesis pathways turn out to be a crucial target for the fungicidal compound. However, the recognition mechanism and dynamic behavior of CYP51 in wheat leaf rust… read more here.
Keywords: protein; fungicidal compounds; puccinia triticina; cyp51 ... See more keywords
Disrupting Hepatocyte Cyp51 from Cholesterol Synthesis Leads to Progressive Liver Injury in the Developing Mouse and Decreases RORC Signalling
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DOI: 10.1038/srep40775
Abstract: Development of mice with hepatocyte knockout of lanosterol 14α-demethylase (HCyp51−/−) from cholesterol synthesis is characterized by the progressive onset of liver injury with ductular reaction and fibrosis. These changes begin during puberty and are generally… read more here.
Keywords: liver injury; cyp51; hepatocyte; cholesterol synthesis ... See more keywords
Antitrypanosomal Activity of Sterol 14α-Demethylase (CYP51) Inhibitors VNI and VFV in the Swiss Mouse Models of Chagas Disease Induced by the Trypanosoma cruzi Y Strain
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DOI: 10.1128/aac.02098-16
Abstract: ABSTRACT Chagas disease is a life-threatening infection caused by a variety of genetically diverse strains of the protozoan parasite Trypanosoma cruzi. The current treatment (benznidazole and nifurtimox) is unsatisfactory, and potential alternatives include inhibitors of… read more here.
Keywords: sterol demethylase; cruzi; demethylase cyp51; cyp51 ... See more keywords
Retinoic acid-induced CYP51 nuclear translocation promotes meiosis prophase I process and is correlated to the expression of REC8 and STAG3 in mice
Sign Up to like & getrecommendations! Published in 2018 at "Biology Open"
DOI: 10.1242/bio.035626
Abstract: ABSTRACT Lanosterol 14 α-demethylase (CYP51) plays a crucial role in cholesterol biosynthesis. In gamete development, CYP51 is involved in initiating meiosis resumption in oocytes through its product, meiosis activating sterol (MAS). In this study, CYP51… read more here.
Keywords: meiosis; rec8 stag3; expression; translocation ... See more keywords