Overinduction of CYP51A Gene After Exposure to Azole Antifungals Provides a First Clue to Resistance Mechanism in Fusarium solani Species Complex.
Sign Up to like & getrecommendations! Published in 2018 at "Microbial drug resistance"
DOI: 10.1089/mdr.2017.0311
Abstract: The genus Fusarium is largely represented in fungal infections, not only mostly in plants but also in humans. Fungi belonging to the Fusarium solani species complex (FSSC) are those that are most frequently isolated in… read more here.
Keywords: azole antifungals; solani species; fusarium; resistance ... See more keywords
Deciphering Aspergillus fumigatus cyp51A-mediated triazole resistance by pyrosequencing of respiratory specimens
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Antimicrobial Chemotherapy"
DOI: 10.1093/jac/dkaa357
Abstract: Abstract Background Infections caused by triazole drug-resistant Aspergillus fumigatus are an increasing problem. The sensitivity of standard culture is poor, abrogating susceptibility testing. Early detection of resistance can improve patient outcomes, yet tools for this… read more here.
Keywords: fumigatus; respiratory specimens; resistance; respiratory ... See more keywords
Detection of azole-susceptible and azole-resistant Aspergillus coinfection by cyp51A PCR amplicon melting curve analysis
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Antimicrobial Chemotherapy"
DOI: 10.1093/jac/dkx262
Abstract: Background The AsperGenius® assay is a multiplex real-time PCR test that allows the simultaneous detection of Aspergillus species and identification of the most common mutations in the Aspergillus fumigatus cyp51A gene conferring resistance (TR34/L98H and… read more here.
Keywords: detection; melting curve; azole; azole resistant ... See more keywords
Azole Resistance-Associated Regulatory Motifs within the Promoter of cyp51A in Aspergillus fumigatus
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DOI: 10.1128/spectrum.01209-22
Abstract: First-line treatment of aspergillosis typically involves the use of azole antifungals. Worryingly, their future clinical use is challenged by an alarming increase in resistance. ABSTRACT Aspergillus fumigatus is one of the deadliest fungal species, causing… read more here.
Keywords: promoter; hapx; iron; cyp51a ... See more keywords
Examination of Cyp51A-Mediated Azole Resistance in Aspergillus lentulus Using CRISPR/Cas9 Genome Editing.
Sign Up to like & getrecommendations! Published in 2022 at "Medical mycology journal"
DOI: 10.3314/mmj.21-00024
Abstract: Aspergillus lentulus was first reported in 2005 as a cryptic species of Aspergillus fumigatus, and since then, its resistance to azole drugs and the high mortality rate of infected individuals have emerged as problems. Although… read more here.
Keywords: crispr cas9; cyp51a; resistance; azole resistance ... See more keywords
Uncovering New Mutations Conferring Azole Resistance in the Aspergillus fumigatus cyp51A Gene
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2019.03127
Abstract: The opportunistic pathogen Aspergillus fumigatus has developed worldwide resistance to azoles largely through mutations in cytochromeP450 enzyme Cyp51. In this study, we indicated that in vitro azole situation results in emergence of azole-resistant mutations. There… read more here.
Keywords: aspergillus fumigatus; resistance; azole resistance; cyp51a ... See more keywords
Multiple Mutations and Overexpression in the CYP51A and B Genes Lead to Decreased Sensitivity of Venturia effusa to Tebuconazole
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DOI: 10.3390/cimb44020047
Abstract: Multiple demethylation-inhibiting (DMI) fungicides are used to control pecan scab, caused by Venturia effusa. To compare the efficacy of various DMI fungicides on V. effusa, field trials were conducted at multiple locations applying fungicides to… read more here.
Keywords: venturia effusa; sensitivity; effusa tebuconazole; cyp51a ... See more keywords
Evidence for the Role of CYP51A and Xenobiotic Detoxification in Differential Sensitivity to Azole Fungicides in Boxwood Blight Pathogens
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DOI: 10.3390/ijms22179255
Abstract: Boxwood blight, a fungal disease of ornamental plants (Buxus spp.), is caused by two sister species, Calonectria pseudonaviculata (Cps) and C. henricotiae (Che). Compared to Cps, Che is documented to display reduced sensitivity to fungicides,… read more here.
Keywords: boxwood blight; xenobiotic detoxification; sensitivity; che ... See more keywords
Azole Resistance and cyp51A Mutation of Aspergillus fumigatus in a Tertiary Referral Hospital in Taiwan
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Fungi"
DOI: 10.3390/jof8090908
Abstract: Azole resistance in Aspergillus fumigatus has increasingly been reported worldwide. Its major mechanism of resistance is mediated by mutations in cyp51A. The objective of this study was to test the antifungal susceptibilities of A. fumigatus… read more here.
Keywords: aspergillus fumigatus; cyp51a; tertiary referral; hospital ... See more keywords