Microplitis bicoloratus parasitism promotes cyclophilin D-p53 interaction to induce apoptosis of hemocytes in Spodoptera litura.
Sign Up to like & getrecommendations! Published in 2022 at "Archives of insect biochemistry and physiology"
DOI: 10.1002/arch.21970
Abstract: Microplitis bicoloratus parasitism can induce apoptosis of hemocytes in the M. bicolortus host, Spodoptera litura. However, it is unclear how M. bicolortus parasitism regulates host signaling pathways to induce apoptosis. Expression of cyclophilin D (CypD)… read more here.
Keywords: parasitism; litura; cypd; induce apoptosis ... See more keywords
Regulation of Sirtuin 3-Mediated Deacetylation of Cyclophilin D Attenuated Cognitive Dysfunction Induced by Sepsis-Associated Encephalopathy in Mice
Sign Up to like & getrecommendations! Published in 2017 at "Cellular and Molecular Neurobiology"
DOI: 10.1007/s10571-017-0476-2
Abstract: The present study aimed to investigate cognitive dysfunction in the hippocampus induced by sepsis-associated encephalopathy (SAE) via acetylation of cyclophilin D (CypD) and opening of mitochondrial permeability transition pore. It also explored whether activating sirtuin… read more here.
Keywords: cypd; group; deacetylation; cognitive dysfunction ... See more keywords
Discovery of non-peptidic small molecule inhibitors of cyclophilin D as neuroprotective agents in Aβ-induced mitochondrial dysfunction
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Computer-Aided Molecular Design"
DOI: 10.1007/s10822-017-0067-9
Abstract: Cyclophilin D (CypD) is a mitochondria-specific cyclophilin that is known to play a pivotal role in the formation of the mitochondrial permeability transition pore (mPTP).The formation and opening of the mPTP disrupt mitochondrial homeostasis, cause… read more here.
Keywords: small molecule; cypd; induced mitochondrial; mitochondrial dysfunction ... See more keywords
Interactions of 17β-Hydroxysteroid Dehydrogenase Type 10 and Cyclophilin D in Alzheimer's Disease
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DOI: 10.1007/s11064-020-02970-y
Abstract: The nucleus-encoded 17β-hydroxysteroid dehydrogenase type 10 (17β-HSD10) regulates cyclophilin D (cypD) in the mitochondrial matrix. CypD regulates opening of mitochondrial permeability transition pores. Both mechanisms may be affected by amyloid β peptides accumulated in mitochondria… read more here.
Keywords: dehydrogenase type; alzheimer disease; cypd; hsd10 cypd ... See more keywords
CypD-mPTP axis regulates mitochondrial functions contributing to osteogenic dysfunction of MC3T3-E1 cells in inflammation
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Physiology and Biochemistry"
DOI: 10.1007/s13105-018-0627-z
Abstract: Bone is a dynamic organ, the bone-forming osteoblasts and bone-resorbing osteoclasts form the physiological basis of bone remodeling process. During pathological process of numerous inflammatory diseases, these two aspects are uncoupled and the balance is… read more here.
Keywords: osteogenic dysfunction; cypd; inflammation; bone ... See more keywords
Mitochondrial PTP Inhibition Through Cyclophilin D Has no Protection Against Non-Reperfused Myocardial Infarction in Female Rats
Sign Up to like & getrecommendations! Published in 2017 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2017.10.169
Abstract: Background Opening of mitochondrial permeability transition pores (mPTP) plays a critical role in pathogenesis of myocardial infarction (MI)/ischemia-reperfusion (IR). Inhibition of cyclophilin D (CypD), a major regulator of the mPTP, is mostly used for prevention… read more here.
Keywords: myocardial infarction; inhibition; cypd; reperfusion ... See more keywords
A novel class of cardioprotective small-molecule PTP inhibitors.
Sign Up to like & getrecommendations! Published in 2019 at "Pharmacological research"
DOI: 10.1016/j.phrs.2019.104548
Abstract: Ischemia/reperfusion (I/R) injury is mediated in large part by opening of the mitochondrial permeability transition pore (PTP). Consequently, inhibitors of the PTP hold great promise for the treatment of a variety of cardiovascular disorders. At… read more here.
Keywords: ptp opening; small molecule; cypd; novel class ... See more keywords
Cyclophilin D Modulates the Cardiac Mitochondrial Target of Isoflurane, Sevoflurane, and Desflurane
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DOI: 10.1097/fjc.0000000000000479
Abstract: Background: Volatile anesthetics are known to limit myocardial ischemia–reperfusion injuries. Mitochondria were shown to be major contributors to cardioprotection. Cyclophilin D (CypD) is one of the main regulators of mitochondria-induced cell death. We compared the… read more here.
Keywords: isoflurane sevoflurane; desflurane; cypd; sevoflurane desflurane ... See more keywords
Cyclophilin D regulates neuronal activity‐induced filopodiagenesis by fine‐tuning dendritic mitochondrial calcium dynamics
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.14484
Abstract: Recent studies have highlighted the role of mitochondria in dendritic protrusion growth and plasticity. However, the detailed mechanisms that mitochondria regulate dendritic filopodia morphogenesis remain elusive. Cyclophilin D (CypD, gene name: Ppif) controls the opening… read more here.
Keywords: regulates neuronal; dendritic mitochondrial; cyclophilin regulates; cypd ... See more keywords
Abstract 734: NF-kB Signaling Regulates Mitochondrial Permeability Transition Pore Opening of Cardiac Myocytes via Cyclophilin D (CypD) Modulation
Sign Up to like & getrecommendations! Published in 2019 at "Circulation Research"
DOI: 10.1161/res.125.suppl_1.734
Abstract: Nuclear Factor-κB (NF-κB) is ubiquitously present transcription factor that regulates a variety of cellular functions including cell survival. Herein, we show a critical role for NF-κB signaling in regulation of mitochondrial permeability transition pore opening… read more here.
Keywords: mitochondrial permeability; cardiac myocytes; cypd; cell death ... See more keywords
Delayed Wound Healing in Mice with Impaired Procoagulant Platelet Formation
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DOI: 10.1182/blood-2018-99-118602
Abstract: Platelets are well recognized as a key player in primary hemostasis and thrombosis, but their role in the subsequent initiation of tissue repair is less well characterized. Within the hemostatic thrombus, ballooned platelets reminiscent of… read more here.
Keywords: wound healing; cypd; role; delayed wound ... See more keywords