Blood-based detection of lung cancer using cysteine-rich angiogenic inducer 61 (CYR61) as a circulating protein biomarker: a pilot study.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular oncology"
DOI: 10.1002/1878-0261.13099
Abstract: Lung cancer is the most often diagnosed cancer and the main cause of cancer deaths in the world compared to other tumor entities. To date, the only screening method for high-risk lung cancer patients is… read more here.
Keywords: cancer; cyr61; detection lung; lung cancer ... See more keywords
CYR61/CCN1 Regulates Sclerostin Levels and Bone Maintenance
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DOI: 10.1002/jbmr.3394
Abstract: CYR61/CCN1 is a matricellular protein that resides in the extracellular matrix, but serves regulatory rather than structural roles. CYR61/CCN1 is found in mineralized tissues and has been shown to influence bone healing in vivo and… read more here.
Keywords: cyr61 ccn1; bone; expression; cyr61 ... See more keywords
Cyr61 Alleviates Cholangitis by Inhibiting Cytotoxic Effects of CD8+ T Cells on Biliary Epithelial Cells
Sign Up to like & getrecommendations! Published in 2021 at "Current Medical Science"
DOI: 10.1007/s11596-021-2458-3
Abstract: Primary biliary cholangitis (PBC) is a chronic progressive cholestatic liver disease. In recent years, researchers have found that cysteine-rich angiogenic inducer 61 (Cyr61, also known as CCN1) has a potential role in reducing portal inflammation… read more here.
Keywords: epithelial cells; cytotoxic effects; pbc; cd8 cells ... See more keywords
Tumor necrosis factor‐alpha suppresses the invasion of HTR‐8/SVneo trophoblast cells through microRNA‐145‐5p‐mediated downregulation of Cyr61
Sign Up to like & getrecommendations! Published in 2018 at "Life Sciences"
DOI: 10.1016/j.lfs.2018.08.005
Abstract: ABSTRACT Deficiency in trophoblast invasion is causally linked to the pathogenesis of preeclampsia. Tumor necrosis factor‐alpha (TNF‐&agr;) shows the ability to suppress the invasiveness of trophoblasts, while cysteine‐rich 61 (Cyr61) exerts an opposite function in… read more here.
Keywords: htr svneo; invasion; tnf agr; trophoblast ... See more keywords
FIMASARTAN REDUCES ANGIOTENSIN II-INDUCED CELLULAR SENESCENCE IN HUMAN CORONARY ARTERY SMOOTH MUSCLE CELLS BY INHIBITING CYR61 AND ERK/P38MAPK/P53 SIGNALING PATHWAY
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Hypertension"
DOI: 10.1097/01.hjh.0000539305.16916.84
Abstract: Objective: Angiotensin II (Ang II) has been linked to vascular senescence; however, the molecular mechanism(s) by which this occurs remain unknown. We hypothesized that Ang II induced vascular smooth muscle cell (SMC) senescence by regulating… read more here.
Keywords: erk; senescence; smooth muscle; p53 ... See more keywords
02.21 Inhibition effects of rosiglitazone, pparγ agonist, on migration and invasion of rheumatoid arthritis-fibroblast like synoviocyte (fls) by down regulating cyr61
Sign Up to like & getrecommendations! Published in 2017 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2016-211050.21
Abstract: Background Peroxisome proliferator-activated receptor gamma (PPARγ) agonist has anti-inflammatory properties, which has known to reduce inflammatory cytokine production in RA. Cysteine-rich angiogenic inducer 61 (Cyr61) is associated with diseases related to chronic inflammation. Cyr61, pro-inflammatory… read more here.
Keywords: invasion; ppar agonist; fls; cyr61 ... See more keywords
FRI0302 Elevated cysteine-rich protein 61 in systemic lupus erythematosus-associated pulmonary arterial hypertension
Sign Up to like & getrecommendations! Published in 2017 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2017-eular.2513
Abstract: Background Pulmonary arterial hypertension (PAH) is a complex and devastating complication of connective tissue diseases that leads to severe morbidity and mortality.Unlike in Caucasians, it is systemic lupus erythematosus that recognized as the the major… read more here.
Keywords: arterial hypertension; pulmonary arterial; sle patients; pah ... See more keywords
AB0243 CYSTEINE RICH 61 (CYR61): A POTENTIAL BIOMARKER ASSOCIATED WITH DISEASE ACTIVITY IN RHEUMATOID ARTHRITIS
Sign Up to like & getrecommendations! Published in 2019 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2019-eular.5222
Abstract: Background Numerous preclinical studies have revealed a critical role of Cysteine rich 61 (Cyr61) in the pathogenesis of rheumatoid arthritis (RA). However, little is known about the potential value of circulation Cyr61 in clinical RA… read more here.
Keywords: disease activity; cyr61; rheumatoid arthritis;
Simvastatin Inhibits CYR61 Expression in Orbital Fibroblasts in Graves' Ophthalmopathy through the Regulation of FoxO3a Signaling
Sign Up to like & getrecommendations! Published in 2021 at "Mediators of Inflammation"
DOI: 10.1155/2021/8888913
Abstract: Graves' ophthalmopathy (GO), which is characterized by orbital tissue inflammation, expansion, and fibrosis, is the ocular manifestation in 25% to 50% of patients with Graves' disease. As the pathology of GO is driven by autoimmune… read more here.
Keywords: graves ophthalmopathy; orbital fibroblasts; cyr61 expression; cultured orbital ... See more keywords
Cyr61 Mediates Angiotensin II-Induced Podocyte Apoptosis via the Upregulation of TXNIP
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Immunology Research"
DOI: 10.1155/2023/8643548
Abstract: Purpose It is well documented that angiotensin II (Ang II) elevation promotes apoptosis of podocytes in vivo and vitro, but the potential mechanism is still oscular. The current study is aimed at probing into the… read more here.
Keywords: cyr61; induced podocyte; expression; ang ... See more keywords
Abstract 3949: CYR61, a member of the CCN protein family, regulates IGF-1 in metastatic prostate cancer
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-3949
Abstract: The cysteine-rich angiogenic inducer 61 (CYR61) is a member of the cellular communication network (CCN) protein family that can be induced by growth factors. CYR61-specific functions are dependent on cellular context. In prostate cancer (PCa),… read more here.
Keywords: cyr61; interaction; ccn protein; pca ... See more keywords