Cis/trans isomerization of proline peptide bonds in the backbone of cyclic disulfide‐bridged peptides
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DOI: 10.1002/pep2.24088
Abstract: Peptides are of interest as potential therapeutic agents, including cyclic disulfide‐bridged peptides because of their limited conformational flexibility and enhanced stability toward proteolysis. To further constrain the flexibility of the peptide backbone, the disulfide‐bridged rings… read more here.
Keywords: cys; peptide bonds; proline peptide; cis trans ... See more keywords
2,2′‐Dipyridyl diselenide: A chemoselective tool for cysteine deprotection and disulfide bond formation
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Peptide Science"
DOI: 10.1002/psc.3236
Abstract: There are many examples of bioactive, disulfide‐rich peptides and proteins whose biological activity relies on proper disulfide connectivity. Regioselective disulfide bond formation is a strategy for the synthesis of these bioactive peptides, but many of… read more here.
Keywords: cys; disulfide bond; bond formation; formation ... See more keywords
Molecular Identification, Characterization, and Expression Analysis of a Metallothionein Gene from Septifer virgatus
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DOI: 10.1007/s10126-020-09970-7
Abstract: This study provides a preliminary characterization of a metallothionein (MT) gene in Septifer virgatus and highlights its potential use in biomonitoring. The full-length SvMT cDNA and the complete sequence of the SvMT gene were identified… read more here.
Keywords: cys cys; cys; exposure; svmt ... See more keywords
A dual-modal probe for NIR fluorogenic and ratiometric photoacoustic imaging of Cys/Hcy in vivo
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DOI: 10.1007/s11426-019-9688-y
Abstract: Biothiols, such as cysteine (Cys) and homocysteine (Hcy), play vital roles in biological homeostasis and are closely related to various pathological and physiological processes in the living systems. Therefore, the in vivo detection of biothiols… read more here.
Keywords: hcy; cys; cys hcy; dual modal ... See more keywords
The Anti-oxidative Effects of Encapsulated Cysteamine During Mice In Vitro Matured Oocyte/Morula-Compact Stage Embryo Culture Model: a Comparison of High-Efficiency Nanocarriers for Hydrophilic Drug Delivery—a Pilot Study
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DOI: 10.1007/s43032-020-00333-0
Abstract: Although it is well-recognized that antioxidant nano-encapsulation has many benefits such as minimizing side effects (e.g., high-dose toxicity), the most attention was paid to the hydrophobic antioxidant not hydrophilic. In this regard, we sought to… read more here.
Keywords: matured oocyte; cys; microscopy; vitro matured ... See more keywords
Ultrasensitive and selective fluorescent sensor for cysteine and application to drug analysis and bioimaging.
Sign Up to like & getrecommendations! Published in 2021 at "Analytical biochemistry"
DOI: 10.1016/j.ab.2021.114138
Abstract: A fluorescent sensor based on coumarin-maleimide conjugate was developed for efficient discrimination of Cys from Hcy and GSH in both organic and aqueous solution. Addition of Cys to the non-fluorescent sensor solution in DMF induced… read more here.
Keywords: cys; fluorescent sensor; solution; drug analysis ... See more keywords
A novel one- and two-photon fluorescent probe induced by light for selective imaging of Cys in living cells and tissues.
Sign Up to like & getrecommendations! Published in 2018 at "Analytica chimica acta"
DOI: 10.1016/j.aca.2018.06.036
Abstract: A novel one- and two-photon fluorescent probe based on a photoreaction was developed for the detection of cysteine (Cys). After it was reacted with Cys and illuminated by light, a strong turn-on fluorescence was observed… read more here.
Keywords: one two; probe; cys; two photon ... See more keywords
l-cysteine-modified metal-organic frameworks as multifunctional probes for efficient identification of N-linked glycopeptides and phosphopeptides in human crystalline lens.
Sign Up to like & getrecommendations! Published in 2019 at "Analytica chimica acta"
DOI: 10.1016/j.aca.2019.01.052
Abstract: Highly selective enrichment of N-linked glycopeptides and phosphopeptides from complex biological samples is extremely important prior to mass spectrometry analysis due to their low abundance as well as numerous extrinsic interferences. In this work, l-cysteine… read more here.
Keywords: cys; metal; human crystalline; glycopeptides phosphopeptides ... See more keywords
A novel off-on fluorescent probe for specific detection and imaging of cysteine in live cells and in vivo
Sign Up to like & getrecommendations! Published in 2020 at "Chinese Chemical Letters"
DOI: 10.1016/j.cclet.2019.05.061
Abstract: Abstract Cysteine (Cys) plays a pivotal role in many physiological and pathological processes, including detoxification and protein synthesis. The abnormal levels of Cys are linked to many diseases. In this study, a novel red-emitting off-on… read more here.
Keywords: fluorescent probe; cys; probe; novel fluorescent ... See more keywords
Sulfhydryl groups as targets of mercury toxicity.
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DOI: 10.1016/j.ccr.2020.213343
Abstract: The present study addresses existing data on the affinity and conjugation of sulfhydryl (thiol; -SH) groups of low- and high-molecular-weight biological ligands with mercury (Hg). The consequences of these interactions with special emphasis on pathways… read more here.
Keywords: thiol groups; cys; groups targets; sulfhydryl groups ... See more keywords
A Quantitative Chemoproteomic Platform to Monitor Selenocysteine Reactivity within a Complex Proteome.
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DOI: 10.1016/j.chembiol.2018.05.017
Abstract: Mammalian selenocysteine (Sec)-containing proteins, selenoproteins, are important to (patho)physiological processes, including redox homeostasis. Sec residues have been recalcitrant to mass spectrometry-based chemoproteomic methods that enrich for reactive cysteine (Cys) residues with electrophilic chemical probes, despite… read more here.
Keywords: sec; cys; chemoproteomic platform; reactivity ... See more keywords