The expression of somatostatin receptor 2 decreases during cyst growth in mice with polycystic kidney disease
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Biology and Medicine"
DOI: 10.1177/1535370218803893
Abstract: Autosomal dominant polycystic kidney disease (ADPKD) is characterized by progressive renal cyst formation and expansion. Several clinical trials show that somatostatin analogs halt cyst growth and progression of ADPKD by inhibiting adenosine 3′,5′-cyclic monophosphate (cAMP)… read more here.
Keywords: cyst growth; kidney disease; polycystic kidney; expression ... See more keywords
Long-term dietary nitrate supplementation does not reduce renal cyst growth in experimental autosomal dominant polycystic kidney disease
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DOI: 10.1371/journal.pone.0248400
Abstract: Augmentation of endogenous nitric oxide (NO) synthesis, either by the classical L-arginine-NO synthase pathway, or the recently discovered entero-salivary nitrate-nitrite-NO system, may slow the progression of autosomal dominant polycystic kidney disease (ADPKD). To test this… read more here.
Keywords: cyst growth; renal cyst; cyst; nitrate supplementation ... See more keywords
Integrin-Linked Kinase Signaling Promotes Cyst Growth and Fibrosis in Polycystic Kidney Disease.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American Society of Nephrology : JASN"
DOI: 10.1681/asn.2016111235
Abstract: Autosomal dominant polycystic kidney disease (ADPKD) is characterized by innumerous fluid-filled cysts and progressive deterioration of renal function. Previously, we showed that periostin, a matricellular protein involved in tissue repair, is markedly overexpressed by cyst… read more here.
Keywords: cyst growth; fibrosis; disease; mice ... See more keywords
Mcp1 Promotes Macrophage-Dependent Cyst Expansion in Autosomal Dominant Polycystic Kidney Disease.
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DOI: 10.1681/asn.2018050518
Abstract: BACKGROUND In patients with autosomal dominant polycystic kidney disease (ADPKD), most of whom have a mutation in PKD1 or PKD2, abnormally large numbers of macrophages accumulate around kidney cysts and promote their growth. Research by… read more here.
Keywords: cyst growth; kidney; mcp1; knockout ... See more keywords
Ferroptosis Promotes Cyst Growth in Autosomal Dominant Polycystic Kidney Disease Mouse Models.
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DOI: 10.1681/asn.2021040460
Abstract: BACKGROUND Autosomal dominant polycystic kidney disease (ADPKD), the most common inherited kidney disease, is regulated by different forms of cell death, including apoptosis and autophagy. However, the role in ADPKD of ferroptosis, a recently discovered… read more here.
Keywords: kidney; ferroptosis; kidney disease; cyst growth ... See more keywords