PF‐06409577 inhibits renal cyst progression by concurrently inhibiting the mTOR pathway and CFTR channel activity
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DOI: 10.1002/2211-5463.13459
Abstract: Renal cyst development and expansion in autosomal dominant polycystic kidney disease (ADPKD) involves over‐proliferation of cyst‐lining epithelial cells and excessive cystic fluid secretion. While metformin effectively inhibits renal cyst growth in mouse models of ADPKD… read more here.
Keywords: cyst; cyst progression; 06409577 inhibits; renal cyst ... See more keywords