Crystal structure of cystathionine β-synthase from honeybee Apis mellifera.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of structural biology"
DOI: 10.1016/j.jsb.2017.12.008
Abstract: Cystathionine β-synthase (CBS), the key enzyme in the transsulfuration pathway, links methionine metabolism to the biosynthesis of cellular redox controlling molecules. CBS catalyzes the pyridoxal-5'-phosphate-dependent condensation of serine and homocysteine to form cystathionine, which is… read more here.
Keywords: crystal structure; apis mellifera; cbs; cystathionine ... See more keywords
Structural Insights into Substrate Specificity of Cystathionine γ-Synthase from Corynebacterium glutamicum.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.7b02391
Abstract: Cystathionine γ-synthase (MetB) condenses O-acetyl-l-homoserine (OAHS) or O-succinyl-l-homoserine (OSHS) with cysteine to produce cystathionine. To investigate the molecular mechanisms and substrate specificity of MetB from Corynebacterium glutamicum (CgMetB), we determined its crystal structure at 1.5… read more here.
Keywords: corynebacterium glutamicum; cystathionine synthase; cystathionine; substrate specificity ... See more keywords
Cystathionine β-synthase is involved in cysteine biosynthesis and H2S generation in Toxoplasma gondii
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DOI: 10.1038/s41598-020-71469-x
Abstract: Cystathionine β-synthase (CBS) catalyzes the condensation of serine and homocysteine to water and cystathionine, which is then hydrolyzed to cysteine, α-ketobutyrate and ammonia by cystathionine γ-lyase (CGL) in the reverse transsulfuration pathway. The protozoan parasite… read more here.
Keywords: cystathionine synthase; gondii; cystathionine; toxoplasma gondii ... See more keywords
E2β Stimulates Ovine Uterine Artery Endothelial Cell H2S Production in vitro by Estrogen Receptor-Dependent Upregulation of Cystathionine β-Synthase and Cystathionine γ -Lyase Expression†
Sign Up to like & getrecommendations! Published in 2018 at "Biology of Reproduction"
DOI: 10.1093/biolre/ioy207
Abstract: Abstract Endogenous hydrogen sulfide (H2S) is a potent vasodilator and proangiogenic second messenger synthesized from L-cysteine by cystathionine β-synthase (CBS) and cystathionine γ -lyase (CTH). Estrogens are potent vasodilators that stimulate H2S biosynthesis in uterine… read more here.
Keywords: cbs cth; cystathionine; cth; h2s production ... See more keywords
Cystathionine as a marker for 1p/19q codeleted gliomas by in vivo magnetic resonance spectroscopy.
Sign Up to like & getrecommendations! Published in 2019 at "Neuro-oncology"
DOI: 10.1093/neuonc/noz031
Abstract: BACKGROUND Codeletion of chromosome arms 1p and 19q (1p/19q codeletion) highly benefits diagnosis and prognosis in gliomas. In this study, we investigated the effect of 1p/19q codeletion on cancer cell metabolism and evaluated possible metabolic… read more here.
Keywords: codeleted gliomas; gliomas; magnetic resonance; cystathionine ... See more keywords
Cystathionine Promotes the Proliferation of Human Astrocytoma U373 Cells
Sign Up to like & getrecommendations! Published in 2018 at "AntiCancer Research"
DOI: 10.21873/anticanres.12621
Abstract: Background/Aim: In certain cancers, accumulation of cystathionine has been observed. The present study investigated the effect of cystathionine on astrocytoma (U373) cell proliferation, the activity of γ-cystathionase (CTH) and changes in thiols levels. Materials and… read more here.
Keywords: u373 cells; proliferation; cystathionine; astrocytoma u373 ... See more keywords
Role for Cystathionine γ Lyase (CSE) in an Ethanol (E)-Induced Lesion in Fetal Brain GSH Homeostasis
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms19051537
Abstract: Earlier, we reported that gestational ethanol (E) can dysregulate neuron glutathione (GSH) homeostasis partially via impairing the EAAC1-mediated inward transport of Cysteine (Cys) and this can affect fetal brain development. In this study, we investigated… read more here.
Keywords: cse; cystathionine; fetal brain; gsh homeostasis ... See more keywords