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   Articles with "cystathionine" as a keyword



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Crystal structure of cystathionine β-synthase from honeybee Apis mellifera.

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recommendations! Published in 2018 at "Journal of structural biology"

DOI: 10.1016/j.jsb.2017.12.008

Abstract: Cystathionine β-synthase (CBS), the key enzyme in the transsulfuration pathway, links methionine metabolism to the biosynthesis of cellular redox controlling molecules. CBS catalyzes the pyridoxal-5'-phosphate-dependent condensation of serine and homocysteine to form cystathionine, which is… read more here.

Keywords: crystal structure; apis mellifera; cbs; cystathionine ... See more keywords
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Structural Insights into Substrate Specificity of Cystathionine γ-Synthase from Corynebacterium glutamicum.

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recommendations! Published in 2017 at "Journal of agricultural and food chemistry"

DOI: 10.1021/acs.jafc.7b02391

Abstract: Cystathionine γ-synthase (MetB) condenses O-acetyl-l-homoserine (OAHS) or O-succinyl-l-homoserine (OSHS) with cysteine to produce cystathionine. To investigate the molecular mechanisms and substrate specificity of MetB from Corynebacterium glutamicum (CgMetB), we determined its crystal structure at 1.5… read more here.

Keywords: corynebacterium glutamicum; cystathionine synthase; cystathionine; substrate specificity ... See more keywords

Cystathionine β-synthase is involved in cysteine biosynthesis and H2S generation in Toxoplasma gondii

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recommendations! Published in 2020 at "Scientific Reports"

DOI: 10.1038/s41598-020-71469-x

Abstract: Cystathionine β-synthase (CBS) catalyzes the condensation of serine and homocysteine to water and cystathionine, which is then hydrolyzed to cysteine, α-ketobutyrate and ammonia by cystathionine γ-lyase (CGL) in the reverse transsulfuration pathway. The protozoan parasite… read more here.

Keywords: cystathionine synthase; gondii; cystathionine; toxoplasma gondii ... See more keywords
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E2β Stimulates Ovine Uterine Artery Endothelial Cell H2S Production in vitro by Estrogen Receptor-Dependent Upregulation of Cystathionine β-Synthase and Cystathionine γ -Lyase Expression†

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recommendations! Published in 2018 at "Biology of Reproduction"

DOI: 10.1093/biolre/ioy207

Abstract: Abstract Endogenous hydrogen sulfide (H2S) is a potent vasodilator and proangiogenic second messenger synthesized from L-cysteine by cystathionine β-synthase (CBS) and cystathionine γ -lyase (CTH). Estrogens are potent vasodilators that stimulate H2S biosynthesis in uterine… read more here.

Keywords: cbs cth; cystathionine; cth; h2s production ... See more keywords
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Cystathionine as a marker for 1p/19q codeleted gliomas by in vivo magnetic resonance spectroscopy.

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recommendations! Published in 2019 at "Neuro-oncology"

DOI: 10.1093/neuonc/noz031

Abstract: BACKGROUND Codeletion of chromosome arms 1p and 19q (1p/19q codeletion) highly benefits diagnosis and prognosis in gliomas. In this study, we investigated the effect of 1p/19q codeletion on cancer cell metabolism and evaluated possible metabolic… read more here.

Keywords: codeleted gliomas; gliomas; magnetic resonance; cystathionine ... See more keywords
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Cystathionine Promotes the Proliferation of Human Astrocytoma U373 Cells

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recommendations! Published in 2018 at "AntiCancer Research"

DOI: 10.21873/anticanres.12621

Abstract: Background/Aim: In certain cancers, accumulation of cystathionine has been observed. The present study investigated the effect of cystathionine on astrocytoma (U373) cell proliferation, the activity of γ-cystathionase (CTH) and changes in thiols levels. Materials and… read more here.

Keywords: u373 cells; proliferation; cystathionine; astrocytoma u373 ... See more keywords
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Role for Cystathionine γ Lyase (CSE) in an Ethanol (E)-Induced Lesion in Fetal Brain GSH Homeostasis

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recommendations! Published in 2018 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms19051537

Abstract: Earlier, we reported that gestational ethanol (E) can dysregulate neuron glutathione (GSH) homeostasis partially via impairing the EAAC1-mediated inward transport of Cysteine (Cys) and this can affect fetal brain development. In this study, we investigated… read more here.

Keywords: cse; cystathionine; fetal brain; gsh homeostasis ... See more keywords