Genome-wide characterization and expression analysis of cystathionine β-synthase genes in plant development and abiotic stresses of cotton (Gossypium spp.).
Sign Up to like & getrecommendations! Published in 2021 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2021.10.079
Abstract: Cystathionine β-synthase (CBS) domains containing proteins (CDCPs) form a large family and play roles in development via regulation of the thioredoxin system as well as abiotic and biotic stress responses of plant. However, the comprehensive… read more here.
Keywords: plant; genes plant; cbs genes; development ... See more keywords
Crystal structure of cystathionine β-synthase from honeybee Apis mellifera.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of structural biology"
DOI: 10.1016/j.jsb.2017.12.008
Abstract: Cystathionine β-synthase (CBS), the key enzyme in the transsulfuration pathway, links methionine metabolism to the biosynthesis of cellular redox controlling molecules. CBS catalyzes the pyridoxal-5'-phosphate-dependent condensation of serine and homocysteine to form cystathionine, which is… read more here.
Keywords: crystal structure; apis mellifera; cbs; cystathionine ... See more keywords
Structural Insights into Substrate Specificity of Cystathionine γ-Synthase from Corynebacterium glutamicum.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.7b02391
Abstract: Cystathionine γ-synthase (MetB) condenses O-acetyl-l-homoserine (OAHS) or O-succinyl-l-homoserine (OSHS) with cysteine to produce cystathionine. To investigate the molecular mechanisms and substrate specificity of MetB from Corynebacterium glutamicum (CgMetB), we determined its crystal structure at 1.5… read more here.
Keywords: corynebacterium glutamicum; cystathionine synthase; cystathionine; substrate specificity ... See more keywords
A hypomorphic cystathionine ß-synthase gene contributes to cavefish eye loss by disrupting optic vasculature
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-16497-x
Abstract: Vestigial structures are key indicators of evolutionary descent, but the mechanisms underlying their development are poorly understood. This study examines vestigial eye formation in the teleost Astyanax mexicanus, which consists of a sighted surface-dwelling morph… read more here.
Keywords: cystathionine synthase; loss; eye; optic vasculature ... See more keywords
Cystathionine β-synthase is involved in cysteine biosynthesis and H2S generation in Toxoplasma gondii
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-71469-x
Abstract: Cystathionine β-synthase (CBS) catalyzes the condensation of serine and homocysteine to water and cystathionine, which is then hydrolyzed to cysteine, α-ketobutyrate and ammonia by cystathionine γ-lyase (CGL) in the reverse transsulfuration pathway. The protozoan parasite… read more here.
Keywords: cystathionine synthase; gondii; cystathionine; toxoplasma gondii ... See more keywords
Therapeutic targets in homocystinuria due to cystathionine β-synthase deficiency: new European guidelines
Sign Up to like & getrecommendations! Published in 2017 at "Expert Opinion on Orphan Drugs"
DOI: 10.1080/21678707.2017.1259561
Abstract: It is just over 50 years since classical homocystinuria was first described independently in 1962 by Carson and Neill in Northern Ireland and Gerritsen and colleagues in Madison, Wisconsin [1,2]. In both cases, patients were… read more here.
Keywords: cystathionine synthase; deficiency; therapeutic targets; synthase deficiency ... See more keywords
L‐cysteine/cystathionine‐β‐synthase‐induced relaxation in mouse aorta involves a L‐serine/sphingosine‐1‐phosphate/NO pathway
Sign Up to like & getrecommendations! Published in 2019 at "British Journal of Pharmacology"
DOI: 10.1111/bph.14654
Abstract: Among the three enzymes involved in the transsulfuration pathway, only cystathionine β‐synthase (CBS) converts L‐cysteine into L‐serine and H2S. L‐serine is also involved in the de novo sphingolipid biosynthesis through a condensation with palmitoyl‐CoA by… read more here.
Keywords: synthase; cysteine cystathionine; relaxation mouse; synthase induced ... See more keywords
Cystathionine β‐synthase is required for oocyte quality by ensuring proper meiotic spindle assembly
Sign Up to like & getrecommendations! Published in 2022 at "Cell Proliferation"
DOI: 10.1111/cpr.13322
Abstract: Poor oocyte quality is detrimental to fertilization and embryo development, which causes infertility. Cystathionine β‐synthase (CBS) is one of the key enzymes modulating the metabolism of homocysteine (Hcy). Studies have shown that CBS plays an… read more here.
Keywords: quality; cystathionine synthase; synthase required; oocyte quality ... See more keywords
S-Adenosylmethionine–responsive cystathionine β-synthase modulates sulfur metabolism and redox balance in Mycobacterium tuberculosis
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abo0097
Abstract: Methionine and cysteine metabolisms are important for the survival and pathogenesis of Mycobacterium tuberculosis (Mtb). The transsulfuration pathway converts methionine to cysteine and represents an important link between antioxidant and methylation metabolism in diverse organisms.… read more here.
Keywords: mycobacterium tuberculosis; metabolism; sam; sulfur metabolism ... See more keywords
Inhibition of fungal pathogenicity by targeting the H2S-synthesizing enzyme cystathionine β-synthase
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.add5366
Abstract: The global emergence of antifungal resistance threatens the limited arsenal of available treatments and emphasizes the urgent need for alternative antifungal agents. Targeting fungal pathogenic functions is an appealing alternative therapeutic strategy. Here, we show… read more here.
Keywords: cystathionine synthase; inhibition fungal; synthase; fungal pathogenicity ... See more keywords
Hyperhomocysteinemia and dyslipidemia in point mutation G307S of cystathionine β-synthase-deficient rabbit generated using CRISPR/Cas9
Sign Up to like & getrecommendations! Published in 2020 at "Lipids in Health and Disease"
DOI: 10.1186/s12944-020-01394-5
Abstract: Background Congenital hyper-homocysteinemia (HHcy) is caused by a defective cystathionine β-synthase ( CBS ) gene, and is frequently associated with dyslipdemia. The aim of this study was to further elucidate the effect of mutated CBS… read more here.
Keywords: mutation; cbs gene; cbs; rabbit ... See more keywords