Structural analysis of Atopobium parvulum SufS cysteine desulfurase linked to Crohn's disease
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14295
Abstract: Crohn’s disease (CD) is characterized by the chronic inflammation of the gastrointestinal tract. A dysbiotic microbiome and a defective immune system are linked to CD, where hydrogen sulfide (H2S) microbial producers positively correlate with the… read more here.
Keywords: structural analysis; atopobium parvulum; crohn disease; cysteine ... See more keywords
Quantum Mechanical Derived (VdW‐DFT) Transferable Lennard–Jones and Morse Potentials to Model Cysteine and Alkanethiol Adsorption on Au(111)
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Materials Interfaces"
DOI: 10.1002/admi.202400369
Abstract: The cysteine and alkanethiol adsorption on Au(111) surfaces is investigated using density functional theory (DFT) and classic molecular dynamics (MD). Understanding the S–Au interaction across different scales poses major challenges. DFT provides atomic‐level precision but… read more here.
Keywords: cysteine alkanethiol; alkanethiol adsorption; morse potentials; cysteine ... See more keywords
Mammalian D‐cysteine: A novel regulator of neural progenitor cell proliferation
Sign Up to like & getrecommendations! Published in 2022 at "BioEssays"
DOI: 10.1002/bies.202200002
Abstract: D‐amino acids are being recognized as functionally important molecules in mammals. We recently identified endogenous D‐cysteine in mammalian brain. D‐cysteine is present in neonatal brain in substantial amounts (mM) and decreases with postnatal development. D‐cysteine… read more here.
Keywords: cell; proliferation; neural progenitor; regulator ... See more keywords
Engineering of the Lrp/AsnC‐type transcriptional regulator DecR as a genetically encoded biosensor for multilevel optimization of L‐cysteine biosynthesis pathway in Escherichia coli
Sign Up to like & getrecommendations! Published in 2024 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.28716
Abstract: L‐cysteine is an important sulfur‐containing amino acid being difficult to produce by microbial fermentation. Due to the lack of high‐throughput screening methods, existing genetically engineered bacteria have been developed by simply optimizing the expression of… read more here.
Keywords: escherichia coli; biosensor; optimization cysteine; cysteine ... See more keywords
Proteome‐Wide Survey of Cysteine Oxidation by Using a Norbornene Probe
Sign Up to like & getrecommendations! Published in 2019 at "ChemBioChem"
DOI: 10.1002/cbic.201900729
Abstract: Rapid detection of cysteine oxidation in living cells is critical in advancing our understanding of responses to reactive oxygen species (ROS) and oxidative stress. Accordingly, there is a need to develop chemical probes that facilitate… read more here.
Keywords: oxidation; cysteine; norbornene probe; cysteine oxidation ... See more keywords
Mammalian D-Cysteine: A new addition to the growing family of biologically relevant D-amino acids.
Sign Up to like & getrecommendations! Published in 2023 at "Chirality"
DOI: 10.1002/chir.23555
Abstract: Mammalian D-Cysteine is racemized from L-cysteine by serine racemase, a pyridoxal phosphate (PLP)-dependent enzyme. Endogenous D-Cysteine plays a role in neural development by inhibiting proliferation of neural progenitor cells (NPCs) via protein kinase B (AKT)… read more here.
Keywords: cysteine new; family; mammalian cysteine; new addition ... See more keywords
Operationally Convenient and Scalable Asymmetric Synthesis of (2S)‐ and (2R)‐α‐(Methyl)cysteine Derivatives through Alkylation of Chiral Alanine Schiff Base NiII Complexes
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Organic Chemistry"
DOI: 10.1002/ejoc.201700018
Abstract: This research demonstrates that the methylation of N-benzyl cysteine Schiff bases derived Ni(II) complexes leads to the formation of the corresponding dehydroalanine containing products and cannot be used for preparation of the target -(methyl)cysteine. In… read more here.
Keywords: alanine schiff; cysteine; methyl cysteine; convenient scalable ... See more keywords
Imaged Capillary Isoelectric Focusing Coupled to High‐Resolution Mass Spectrometry (icIEF‐MS) for Cysteine‐Linked Antibody–Drug Conjugate (ADC) Heterogeneity Characterization Under Native Condition
Sign Up to like & getrecommendations! Published in 2024 at "ELECTROPHORESIS"
DOI: 10.1002/elps.202400083
Abstract: Native mass spectrometry (nMS) is a cutting‐edge technique that leverages electrospray ionization MS (ESI‐MS) to investigate large biomolecules and their complexes in solution. The goal of nMS is to retain the native structural features and… read more here.
Keywords: imaged capillary; mass spectrometry; drug; cysteine linked ... See more keywords
A novel, industrially‐feasible synthetic route to (+)‐biotin from L‐cysteine
Sign Up to like & getrecommendations! Published in 2024 at "Helvetica Chimica Acta"
DOI: 10.1002/hlca.202400090
Abstract: A novel, industrially viable synthetic route to (+)‐biotin has been developed starting from L‐cysteine via the known key thiolactone intermediate. The route takes advantage of the in‐built stereochemistry of the cysteine starting material and the… read more here.
Keywords: novel industrially; cysteine; route; route biotin ... See more keywords
Biochemical characterization of argininosuccinate lyase from M. tuberculosis: significance of a c‐terminal cysteine in catalysis and thermal stability
Sign Up to like & getrecommendations! Published in 2017 at "IUBMB Life"
DOI: 10.1002/iub.1683
Abstract: Arginine biosynthesis pathway is crucial to the survival and pathogenesis of Mycobacterium tuberculosis (Mtb). Arginine is a critical amino acid that contributes to the inflection of cellular immune responses during pathogenesis. Argininosuccinate lyase from Mtb… read more here.
Keywords: cysteine; cys441; tuberculosis; activity ... See more keywords
Novel Anti-Biofouling Soft Contact Lens: l-Cysteine Conjugated Amphiphilic Conetworks via RAFT and Thiol-Ene Click Chemistry.
Sign Up to like & getrecommendations! Published in 2017 at "Macromolecular bioscience"
DOI: 10.1002/mabi.201600444
Abstract: A unique l-cysteine conjugated antifouling amphiphilic conetwork (APCN) is synthesized through end-crosslinking of well-defined triblock copolymers poly(allyl methacrylate)-b-poly(ethylene glycol)-b-poly(allyl methacrylate) via a combination of reversible addition-fragmentation chain transfer (RAFT) polymerization and thiol-ene "click" chemistry. The… read more here.
Keywords: click chemistry; raft; cysteine; chemistry ... See more keywords