Serine-/Cysteine-Based sp2-Iminoglycolipids as Novel TLR4 Agonists: Evaluation of Their Adjuvancy and Immunotherapeutic Properties in a Murine Model of Asthma.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01948
Abstract: Glycolipids with TLR4 agonistic properties can serve either as therapeutic agents or as vaccine adjuvants by stimulating the development of proinflammatory responses. Translating them to the clinical setting is hampered by synthetic difficulties, the lack… read more here.
Keywords: serine cysteine; iminoglycolipids novel; based sp2; cysteine based ... See more keywords
Cln5 represents a new type of cysteine-based S-depalmitoylase linked to neurodegeneration
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abj8633
Abstract: Genetic CLN5 variants are associated with childhood neurodegeneration and Alzheimer’s disease; however, the molecular function of ceroid lipofuscinosis neuronal protein 5 (Cln5) is unknown. We solved the Cln5 crystal structure and identified a region homologous… read more here.
Keywords: cysteine; cysteine based; activity; neurodegeneration ... See more keywords
A Novel Photoelectrochemical Assay for Cysteine Based on the Target-Induced Generation of Photosensitizer
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Electrochemical Science"
DOI: 10.20964/2018.07.77
Abstract: 1 College of Chemistry and Chemical Engineering, Shangqiu Normal University, Shangqiu, Henan 476000, People's Republic of China 2 Hunan Institute of Food Quanlity Supervision Inspection and Research, Building B, No. 238, Ave. Timesun, District Yuhua,… read more here.
Keywords: republic china; assay cysteine; cysteine based; novel photoelectrochemical ... See more keywords