Enhanced tumor retention of NTSR1-targeted agents by employing a hydrophilic cysteine cathepsin inhibitor.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.05.068
Abstract: We explored the approach of using an analog of E-64, a well-known and hydrophilic cysteine cathepsin (CC) inhibitor, as a potent cysteine cathepsin-trapping agent (CCTA) to improve the tumor retention of low-molecular-weight, receptor-targeted radiopharmaceuticals. The… read more here.
Keywords: cysteine cathepsin; retention; ntsr1 targeted; tumor retention ... See more keywords
Inhibitory prodrug mechanism for cysteine cathepsin-targeted self-controlled drug release
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2022.2122961
Abstract: Abstract Tumour-associated macrophages (TAMs) support tumour development and have emerged as important regulators of therapeutic response to cytostatic agents. To target TAMs, we have developed a novel drug delivery approach which induces drug release as… read more here.
Keywords: inhibitory prodrug; cysteine cathepsin; drug; drug release ... See more keywords
Cysteine cathepsin C: a novel potential biomarker for the diagnosis and prognosis of glioma
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DOI: 10.1186/s12935-021-02417-6
Abstract: Background Cysteine cathepsin C encoded by the CTSC gene is an important member of the cysteine cathepsin family that plays a key role regulation of many types of tumors. However, whether CTSC is involved in… read more here.
Keywords: expression; prognosis; diagnosis; cysteine cathepsin ... See more keywords