Imaged Capillary Isoelectric Focusing Coupled to High‐Resolution Mass Spectrometry (icIEF‐MS) for Cysteine‐Linked Antibody–Drug Conjugate (ADC) Heterogeneity Characterization Under Native Condition
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DOI: 10.1002/elps.202400083
Abstract: Native mass spectrometry (nMS) is a cutting‐edge technique that leverages electrospray ionization MS (ESI‐MS) to investigate large biomolecules and their complexes in solution. The goal of nMS is to retain the native structural features and… read more here.
Keywords: imaged capillary; mass spectrometry; drug; cysteine linked ... See more keywords
Accurate determination of drug-to-antibody ratio of interchain cysteine-linked antibody–drug conjugates by LC-HRMS
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DOI: 10.1007/s00216-019-02280-5
Abstract: Accurate determination of the drug-to-antibody ratio (DAR) of interchain cysteine-linked antibody–drug conjugates (ADCs) is challenging. High-resolution mass spectrometry (HRMS) analysis of the ADCs at the intact or subunit level provides a feasible way to measure… read more here.
Keywords: dar; cysteine linked; accurate determination; drug ... See more keywords