The Structure‐Function Relationship of Human Bleomycin Hydrolase: Mutation of a Cysteine Protease into a Serine Protease
Sign Up to like & getrecommendations! Published in 2022 at "ChemBioChem"
DOI: 10.1002/cbic.202200186
Abstract: Human bleomycin hydrolase (hBH) catalyzes deamidation of the anticancer drug bleomycins (BLM). This enzyme is involved in BLM detoxification and drug resistance. Herein, we report the putative BLM‐binding site and catalytic mechanism of hBH. The… read more here.
Keywords: protease; cysteine protease; serine protease; bleomycin hydrolase ... See more keywords
The Cyanobacterial “Nutraceutical” Phycocyanobilin Inhibits Cysteine Protease Legumain
Sign Up to like & getrecommendations! Published in 2022 at "ChemBioChem"
DOI: 10.1002/cbic.202200455
Abstract: The blue biliprotein phycocyanin, produced by photo‐autotrophic cyanobacteria including spirulina (Arthrospira) and marketed as a natural food supplement or “nutraceutical,” is reported to have anti‐inflammatory, antioxidant, immunomodulatory, and anticancer activity. These diverse biological activities have… read more here.
Keywords: protease legumain; nutraceutical phycocyanobilin; cyanobacterial nutraceutical; cysteine protease ... See more keywords
Comparative analysis of immune effects in mice model: Clonorchis sinensis cysteine protease generated from recombinant Escherichia coli and Bacillus subtilis spores
Sign Up to like & getrecommendations! Published in 2017 at "Parasitology Research"
DOI: 10.1007/s00436-017-5445-7
Abstract: Clonorchiasis remains a nonnegligible public health problem in endemic areas. Cysteine protease of Clonorchis sinensis (CsCP) plays indispensable roles in the parasitic physiology and pathology, and has been exploited as a promising drug and vaccine… read more here.
Keywords: sinensis; recombinant escherichia; clonorchis sinensis; cscp ... See more keywords
Host-synthesized cysteine protease-specific inhibitor disrupts Cuscuta campestris parasitism in tomato
Sign Up to like & getrecommendations! Published in 2017 at "Plant Biotechnology Reports"
DOI: 10.1007/s11816-017-0451-x
Abstract: Dodder (Cuscuta campestris) is one of the most important pests of tomato causing severe losses in yield. Cuscutain is a pre-pro-protein produced by dodder that has a cysteine proteinase function essential for normal development of… read more here.
Keywords: cuscuta campestris; protease; cysteine protease; tomato ... See more keywords
Identification of cysteine protease inhibitors as new drug leads against Naegleria fowleri.
Sign Up to like & getrecommendations! Published in 2018 at "Experimental parasitology"
DOI: 10.1016/j.exppara.2018.03.010
Abstract: Primary amebic meningoencephalitis (PAM) is a rapidly fatal infection caused by the free-living ameba Naegleria fowleri. PAM occurs principally in healthy children of less than 13 years old with a history of recent exposure to… read more here.
Keywords: protease; fowleri; cysteine protease; drug ... See more keywords
Biotechnological potential of a cysteine protease (CpCP3) from Calotropis procera latex for cheesemaking.
Sign Up to like & getrecommendations! Published in 2019 at "Food chemistry"
DOI: 10.1016/j.foodchem.2019.125574
Abstract: This article reports the characterization and evaluation of the biotechnological potential of a cysteine protease purified from Calotropis procera (CpCP3). This enzyme was highly stable to different metal ions and was able to hydrolyze κ-casein… read more here.
Keywords: biotechnological potential; cpcp3; cysteine protease; potential cysteine ... See more keywords
Purification, biochemical characterization and antioxidant property of ZCPG, a cysteine protease from Zingiber montanum rhizome.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2017.08.078
Abstract: Zingiber montanum cysteine protease glycoprotein (ZCPG) was purified to homogeneity by DEAE- cellulose and Sephadex G50 resulting in sixteen fold purification and total activity of 39.4U/mg. ZCPG presented a prominent single peak in HPLC chromatogram… read more here.
Keywords: zingiber montanum; cysteine protease; zcpg; cysteine ... See more keywords
Crystal structure of chikungunya virus nsP2 cysteine protease reveals a putative flexible loop blocking its active site.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2018.05.007
Abstract: Chikungunya virus (CHIKV), a mosquito-borne pathogenic alphavirus is a growing public health threat. No vaccines or antiviral drug is currently available in the market for chikungunya treatment. nsP2pro, the viral cysteine protease, carries out an… read more here.
Keywords: protease; cysteine protease; structure; loop ... See more keywords
In vitro evaluation of a cysteine protease from poultry red mites, Demanyssus gallinae, as a vaccine antigen for chickens.
Sign Up to like & getrecommendations! Published in 2021 at "Poultry science"
DOI: 10.1016/j.psj.2021.101638
Abstract: Poultry red mites (PRMs, Dermanyssus gallinae) are hematophagous ectoparasites that negatively affect egg production, which causes serious economic losses to the poultry industry worldwide. Currently, the emergence of acaricide-resistant PRMs has impeded PRM control in… read more here.
Keywords: vaccine; poultry; cysteine protease; deg cpr ... See more keywords
Can Cysteine Protease Cross-class Inhibitors Achieve Selectivity?
Sign Up to like & getrecommendations! Published in 2019 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.9b00683
Abstract: Cysteine proteases are important targets for the discovery of novel therapeutics for many human diseases. From parasitic diseases to cancer, cysteine proteases follow a common mechanism, the formation of an encounter complex with subsequent nucleophilic… read more here.
Keywords: cysteine; cysteine protease; cross; achieve selectivity ... See more keywords
Computational Study of the Catalytic Mechanism of the Cruzain Cysteine Protease
Sign Up to like & getrecommendations! Published in 2017 at "ACS Catalysis"
DOI: 10.1021/acscatal.6b03096
Abstract: Cysteine proteases of the papain family are involved in many diseases, making them attractive targets for developing drugs. In this paper, different catalytic mechanisms of cruzain cysteine protease have been studied on the basis of… read more here.
Keywords: cruzain cysteine; mechanism; computational study; cysteine protease ... See more keywords