Activities of Vacuolar Cysteine Proteases in Plant Senescence.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7672-0_22
Abstract: Plant senescence is accompanied by a marked increase in proteolytic activities, and cysteine proteases (Cys-protease) represent the prevailing class among the responsible proteases. Cys-proteases predominantly locate to lytic compartments, i.e., to the central vacuole (CV)… read more here.
Keywords: cys proteases; senescence; cysteine proteases; plant senescence ... See more keywords
Dipeptidyl nitrile derivatives suppress the Trypanosoma cruzi in vitro infection.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental parasitology"
DOI: 10.1016/j.exppara.2020.108032
Abstract: Chagas disease affects several countries around the world with health and sanitation problems. Cysteine proteases are essential for the virulence and replication of the Trypanosoma cruzi, being modulated by dipeptidyl nitriles and derivatives. Here, four… read more here.
Keywords: dipeptidyl nitrile; nitrile derivatives; cysteine proteases; cruzi ... See more keywords
Novel biotechnological formulations of cysteine proteases, immobilized on chitosan. Structure, stability and activity.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2021.03.016
Abstract: Bromelain, papain, and ficin are studied the most for meat tenderization, but have limited application due to their short lifetime. The aim of this work is to identify the adsorption mechanisms of these cysteine proteases… read more here.
Keywords: immobilization; cysteine proteases; novel biotechnological; structure ... See more keywords
Testing Affordable Strategies for the Computational Study of Reactivity in Cysteine Proteases: The Case of SARS-CoV-2 3CL Protease Inhibition
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Chemical Theory and Computation"
DOI: 10.1021/acs.jctc.2c00294
Abstract: Cysteine proteases are an important target for the development of inhibitors that could be used as drugs to regulate the activity of these kinds of enzymes involved in many diseases, including COVID-19. For this reason,… read more here.
Keywords: cysteine proteases; 3cl protease; cov 3cl; study ... See more keywords
Self-Masked Aldehyde Inhibitors: A Novel Strategy for Inhibiting Cysteine Proteases.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c00628
Abstract: Cysteine proteases comprise an important class of drug targets, especially for infectious diseases such as Chagas disease (cruzain) and COVID-19 (3CL protease, cathepsin L). Peptide aldehydes have proven to be potent inhibitors for all of… read more here.
Keywords: aldehyde inhibitors; cysteine; masked aldehyde; self masked ... See more keywords
Impact of the Recognition Part of Dipeptidyl Nitroalkene Compounds on the Inhibition Mechanism of Cysteine Proteases Cruzain and Cathepsin L
Sign Up to like & getrecommendations! Published in 2023 at "ACS Catalysis"
DOI: 10.1021/acscatal.3c01035
Abstract: Cysteine proteases (CPs) are an important class of enzymes, many of which are responsible for several human diseases. For instance, cruzain of protozoan parasite Trypanosoma cruzi is responsible for the Chagas disease, while the role… read more here.
Keywords: cysteine proteases; nitroalkene compounds; impact recognition; inhibition ... See more keywords
Genome-wide survey of soybean papain-like cysteine proteases and their expression analysis in root nodule symbiosis
Sign Up to like & getrecommendations! Published in 2020 at "BMC Plant Biology"
DOI: 10.1186/s12870-020-02725-5
Abstract: Background Plant papain-like cysteine proteases ( PLCPs ) are a large class of proteolytic enzymes and play important roles in root nodule symbiosis (RNS), while the whole-genome studies of PLCP family genes in legume are… read more here.
Keywords: root nodule; like cysteine; symbiosis; gmplcps ... See more keywords
Cysteine proteases as digestive enzymes in parasitic helminths
Sign Up to like & getrecommendations! Published in 2018 at "PLoS Neglected Tropical Diseases"
DOI: 10.1371/journal.pntd.0005840
Abstract: We briefly review cysteine proteases (orthologs of mammalian cathepsins B, L, F, and C) that are expressed in flatworm and nematode parasites. Emphasis is placed on enzyme activities that have been functionally characterized, are associated… read more here.
Keywords: digestive enzymes; cysteine proteases; proteases digestive; enzymes parasitic ... See more keywords
Update on drug development targeting parasite cysteine proteases
Sign Up to like & getrecommendations! Published in 2018 at "PLoS Neglected Tropical Diseases"
DOI: 10.1371/journal.pntd.0005850
Abstract: As noted in the introductory review, cysteine proteases are attractive targets for structurebased drug design because of their well-defined active site topology and mechanism of action, available high-throughput assays, and known drugability. Drugs targeting human… read more here.
Keywords: drug development; cysteine proteases; cathepsin; cysteine ... See more keywords
Structure-Based Approaches Targeting Parasite Cysteine Proteases.
Sign Up to like & getrecommendations! Published in 2017 at "Current medicinal chemistry"
DOI: 10.2174/0929867324666170810165302
Abstract: Cysteine proteases are essential hydrolytic enzymes present in the majority of organisms, including viruses and unicellular parasites. Despite the high sequence identity displayed among these proteins, specific structural features across different species grant distinct functions… read more here.
Keywords: based approaches; structure based; approaches targeting; cysteine proteases ... See more keywords
Inhibitor of Cysteine Protease of Plasmodium malariae Regulates Malapains, Endogenous Cysteine Proteases of the Parasite
Sign Up to like & getrecommendations! Published in 2022 at "Pathogens"
DOI: 10.3390/pathogens11050605
Abstract: Cysteine proteases of malaria parasites have been recognized as potential targets in antimalarial drug development as they play pivotal roles in the biology of these parasites. However, strict regulation of their activities is also necessary… read more here.
Keywords: cysteine proteases; inhibitor cysteine; pmicp; plasmodium malariae ... See more keywords