Cysteine-reactive probes and their use in chemical proteomics.
Sign Up to like & getrecommendations! Published in 2018 at "Chemical communications"
DOI: 10.1039/c8cc01485j
Abstract: Proteomic profiling using bioorthogonal chemical probes that selectively react with certain amino acids is now a widely used method in life sciences to investigate enzymatic activities, study posttranslational modifications and discover novel covalent inhibitors. Over… read more here.
Keywords: amino acids; cysteine reactive; chemical proteomics; use chemical ... See more keywords
Abstract 4024: Overcoming ALK resistance with covalent cysteine-reactive inhibitors in lung cancer
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-4024
Abstract: The EML4-ALK fusion gene is the main oncogenic driver in 5% of non-small cell lung cancer and has been effectively targeted using ALK-specific tyrosine kinase inhibitors. While survival rates have improved steadily with each new… read more here.
Keywords: alk; cysteine reactive; cancer; alk resistance ... See more keywords