Engaging a Non-catalytic Cysteine Residue Drives Potent and Selective Inhibition of Caspase-6
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c12240
Abstract: Caspases are a family of cysteine-dependent proteases with important cellular functions in inflammation and apoptosis, while also implicated in human diseases. Classical chemical tools to study caspase functions lack selectivity for specific caspase family members… read more here.
Keywords: non catalytic; cysteine residue; catalytic cysteine; caspase ... See more keywords
Covalent Warheads Targeting Cysteine Residue: The Promising Approach in Drug Development
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DOI: 10.3390/molecules27227728
Abstract: Cysteine is one of the least abundant amino acids in proteins of many organisms, which plays a crucial role in catalysis, signal transduction, and redox regulation of gene expression. The thiol group of cysteine possesses… read more here.
Keywords: development; cysteine; covalent warheads; cysteine residue ... See more keywords
A Conserved Cysteine Residue in Coxsackievirus B3 Protein 3A with Implication for Elevated Virulence
Sign Up to like & getrecommendations! Published in 2022 at "Viruses"
DOI: 10.3390/v14040769
Abstract: Enteroviruses (EV) are implicated in an extensive range of clinical manifestations, such as pancreatic failure, cardiovascular disease, hepatitis, and meningoencephalitis. We recently reported on the biochemical properties of the highly conserved cysteine residue at position… read more here.
Keywords: coxsackievirus protein; cysteine residue; cvb3; conserved cysteine ... See more keywords