Structural characterization of a monomethylauristatin-E based ADC that contains 8 drugs conjugated at interchain cysteine residues.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of pharmaceutical and biomedical analysis"
DOI: 10.1016/j.jpba.2021.114309
Abstract: Antibody-drug conjugates (ADCs) with a drug-to-antibody ratio (DAR) of 8 are attractive as therapeutic anti-cancer agents due to the higher levels of cytotoxic payload delivered to tumors. Biophysical characterization of a DAR 8 ADC fully… read more here.
Keywords: dar adc; conjugated interchain; cysteine residues; stability ... See more keywords
The allergen Mus m 1.0102: Cysteine residues and molecular allergology.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular immunology"
DOI: 10.1016/j.molimm.2020.01.022
Abstract: Mus m 1.0102 is a member of the mouse Major Urinary Protein family, belonging to the Lipocalins superfamily. Major Urinary Proteins (MUPs) are characterized by highly conserved structural motifs. These include a disulphide bond, involved… read more here.
Keywords: protein; cysteine; mus 0102; allergen mus ... See more keywords
Three cysteine residues of SLC52A1, a receptor for the porcine endogenous retrovirus-A (PERV-A), play a critical role in cell surface expression and infectivity.
Sign Up to like & getrecommendations! Published in 2017 at "Virology"
DOI: 10.1016/j.virol.2017.04.019
Abstract: Porcine endogenous retrovirus-A (PERV-A), a gammaretrovirus, infects human cells in vitro, thus raising the potential risk of cross-species transmission in xenotransplantation. Two members of the solute carrier family 52 (SLC52A1 and SLC52A2) are PERV-A receptors.… read more here.
Keywords: receptor; cysteine residues; surface expression; perv ... See more keywords
2H-Azirines as Potential Bifunctional Chemical Linkers of Cysteine Residues in Bioconjugate Technology.
Sign Up to like & getrecommendations! Published in 2020 at "Organic letters"
DOI: 10.1021/acs.orglett.0c00415
Abstract: 2H-Azirine-2-caboxamides have been designed to perform as a new type of bifunctional thiol linker under very mild reaction conditions. The cleavage of a C-N double bond of 2H-azirine furnishes an amino amide functional group in… read more here.
Keywords: potential bifunctional; linkers cysteine; bifunctional chemical; chemical linkers ... See more keywords
Evaluation of Chemically-Cleavable Linkers for Quantitative Mapping of Small Molecule-Cysteinome Reactivity.
Sign Up to like & getrecommendations! Published in 2019 at "ACS chemical biology"
DOI: 10.1021/acschembio.9b00424
Abstract: Numerous reagents have been developed to enable chemical proteomic analysis of small molecule-protein interactomes. However, the performance of these reagents has not been systematically evaluated and compared. Herein, we report our efforts to conduct a… read more here.
Keywords: cysteine residues; small molecule; chemically cleavable; linker ... See more keywords
Cysteine residues in mitochondrial intermembrane space proteins: more than just import
Sign Up to like & getrecommendations! Published in 2019 at "British Journal of Pharmacology"
DOI: 10.1111/bph.14480
Abstract: The intermembrane space (IMS) is a very small mitochondrial sub‐compartment with critical relevance for many cellular processes. IMS proteins fulfil important functions in transport of proteins, lipids, metabolites and metal ions, in signalling, in metabolism… read more here.
Keywords: residues mitochondrial; cysteine residues; intermembrane space; ims proteins ... See more keywords
Redox regulation of the yeast voltage-gated Ca2+ channel homolog Cch1p by glutathionylation of specific cysteine residues
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cell Science"
DOI: 10.1242/jcs.202853
Abstract: ABSTRACT Cch1p, the yeast homolog of the pore-forming subunit α1 of the mammalian voltage-gated Ca2+ channel (VGCC), is located on the plasma membrane and mediates the redox-dependent influx of Ca2+. Cch1p is known to undergo… read more here.
Keywords: glutathionylation; cch1p; yeast; activation ... See more keywords
Targeting Non-Catalytic Cysteine Residues Through Structure-Guided Drug Discovery.
Sign Up to like & getrecommendations! Published in 2017 at "Current topics in medicinal chemistry"
DOI: 10.2174/1568026616666160719163839
Abstract: The targeting of non-catalytic cysteine residues with small molecules is drawing increased attention from drug discovery scientists and chemical biologists. From a biological perspective, genomic and proteomic studies have revealed the presence of cysteine mutations… read more here.
Keywords: targeting non; cysteine; structure guided; drug ... See more keywords
Arabidopsis Tetraspanins Facilitate Virus Infection via Membrane-Recognition GCCK/RP Motif and Cysteine Residues
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2022.805633
Abstract: Tetraspanins (TETs) function as key molecular scaffolds for surface signal recognition and transduction via the assembly of tetraspanin-enriched microdomains. TETs’ function in mammalian has been intensively investigated for the organization of multimolecular membrane complexes, regulation… read more here.
Keywords: plant; gcck motif; cysteine residues; membrane ... See more keywords
NO and Heme Proteins: Cross-Talk between Heme and Cysteine Residues
Sign Up to like & getrecommendations! Published in 2023 at "Antioxidants"
DOI: 10.3390/antiox12020321
Abstract: Heme proteins are a diverse group that includes several unrelated families. Their biological function is mainly associated with the reactivity of the heme group, which—among several other reactions—can bind to and react with nitric oxide… read more here.
Keywords: nitrosylation; heme cysteine; heme; cysteine residues ... See more keywords
Identifying Redox-Sensitive Cysteine Residues in Mitochondria
Sign Up to like & getrecommendations! Published in 2023 at "Antioxidants"
DOI: 10.3390/antiox12050992
Abstract: The mitochondrion is the primary energy generator of a cell and is a central player in cellular redox regulation. Mitochondrial reactive oxygen species (mtROS) are the natural byproducts of cellular respiration that are critical for… read more here.
Keywords: cysteine oxidation; redox sensitive; oxidation; redox ... See more keywords