Effect of Methylmercury Binding on the Peroxide-Reducing Potential of Cysteine and Selenocysteine.
Sign Up to like & getrecommendations! Published in 2021 at "Inorganic chemistry"
DOI: 10.1021/acs.inorgchem.0c03619
Abstract: Methylmercury (CH3Hg+) binding to catalytically fundamental cysteine and selenocysteine of peroxide-reducing enzymes has long been postulated as the origin of its toxicological activity. Only very recently, CH3Hg+ binding to the selenocysteine of thioredoxin reductase has… read more here.
Keywords: cysteine selenocysteine; selenocysteine; reducing potential; methylmercury ... See more keywords
Reactions of Arsenoplatin-1 with Protein Targets: A Combined Experimental and Theoretical Study
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DOI: 10.1021/acs.inorgchem.1c03732
Abstract: Arsenoplatin-1 (AP-1) is a dual-action anticancer metallodrug with a promising pharmacological profile that features the simultaneous presence of a cisplatin-like center and an arsenite center. We investigated its interactions with proteins through a joint experimental… read more here.
Keywords: experimental theoretical; protein targets; targets combined; reactions arsenoplatin ... See more keywords
Novel Lennard-Jones Parameters for Cysteine and Selenocysteine in the AMBER Force Field
Sign Up to like & getrecommendations! Published in 2023 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.2c01104
Abstract: Cysteine is a common amino acid with a thiol group that plays a pivotal role in a variety of scenarios in redox biochemistry. In contrast, selenocysteine, the 21st amino acid, is only present in 25… read more here.
Keywords: force field; lennard jones; cysteine selenocysteine; parameters cysteine ... See more keywords
Stereoselective α-Deuteration of Serine, Cysteine, Selenocysteine, and 2,3-Diaminopropanoic Acid Derivatives.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c02715
Abstract: Efficient methodologies for synthesizing enantiopure α-deuterated derivatives of serine, cysteine, selenocysteine, and 2,3-diaminopropanoic acid have been developed. H/D exchange was achieved by deprotonation of a chiral bicyclic serine equivalent followed by selective deuteration. Additionally, diastereoselective… read more here.
Keywords: selenocysteine diaminopropanoic; cysteine selenocysteine; diaminopropanoic acid;