Cysteine‐Specific Multifaceted Bioconjugation of Peptides and Proteins Using 5‐Substituted 1,2,3‐Triazines
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202308491
Abstract: Peptide and protein postmodification have gained significant attention due to their extensive impact on biomolecule engineering and drug discovery, of which cysteine‐specific modification strategies are prominent due to their inherent nucleophilicity and low abundance. Herein,… read more here.
Keywords: cysteine specific; specific multifaceted; multifaceted bioconjugation; peptides proteins ... See more keywords
Cysteine-Specific 18F and NIR Dual Labeling of Peptides via Vinyltetrazine Bioorthogonal Conjugation for Molecular Imaging.
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DOI: 10.1021/acs.jmedchem.4c02165
Abstract: Radiolabeled peptides are vital for positron emission tomography (PET) imaging, yet the 18F-labeling peptides remain challenging due to harsh conditions and time-consuming premodification requirements. Herein, we developed a novel vinyltetrazine-mediated bioorthogonal approach for highly efficient… read more here.
Keywords: cysteine specific; nir dual; specific 18f; labeling peptides ... See more keywords
A cysteine-specific solubilizing tag strategy enables efficient chemical protein synthesis of difficult targets
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DOI: 10.1039/d3sc06032b
Abstract: We developed a new cysteine-specific solubilizing tag strategy via a cysteine-conjugated succinimide. This solubilizing tag remains stable under common native chemical ligation conditions and can be efficiently removed with palladium-based catalysts. Utilizing this approach, we… read more here.
Keywords: cysteine specific; specific solubilizing; tag strategy; solubilizing tag ... See more keywords