Targeting UBC9-mediated protein hyper-SUMOylation in cystic cholangiocytes halts polycystic liver disease in experimental models
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DOI: 10.1016/j.jhep.2020.09.010
Abstract: Background & Aims: Polycystic liver diseases (PLDs) are genetic disorders characterized by progressive development of multiple fluid-filled biliary cysts. Most PLD-causative genes participate in protein biogenesis and/or transport. Post-translational modifications (PTMs) are implicated in protein… read more here.
Keywords: sumoylation; protein; polycystic liver; targeting ubc9 ... See more keywords