CYT-Rx20 inhibits ovarian cancer cells in vitro and in vivo through oxidative stress-induced DNA damage and cell apoptosis
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DOI: 10.1007/s00280-017-3330-9
Abstract: AbstractPurpose The β-nitrostyrene family has been previously reported to possess anticancer property. However, the biological effects of β-nitrostyrenes on ovarian cancer and the underlying mechanisms involved remain unclear. In the present study, we synthesized a… read more here.
Keywords: cancer; cyt rx20; cell; ovarian cancer ... See more keywords
3′‐Hydroxy‐4′‐methoxy‐&bgr;‐methyl‐&bgr;‐nitrostyrene inhibits tumor growth through ROS generation and GSH depletion in lung cancer cells
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DOI: 10.1016/j.lfs.2016.12.009
Abstract: Aims: Members of the &bgr;‐nitrostyrene family are known to suppress tumor growth, with the underlying mechanisms of &bgr;‐nitrostyrene remain mostly unclear. Herein, we synthesized a &bgr;‐nitrostyrene derivative, 3′‐hydroxy‐4′‐methoxy‐&bgr;‐methyl‐&bgr;‐nitrostyrene (CYT‐Rx20), and explored its anticancer activities in… read more here.
Keywords: cyt rx20; bgr; lung cancer; bgr nitrostyrene ... See more keywords