A phase II study of combination daunorubicin, cytarabine (Ara‐c), and nilotinib (TAsigna) (DATA) in patients newly diagnosed with acute myeloid leukemia with KIT expression
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DOI: 10.1002/ajh.26831
Abstract: Acute myeloid leukemia (AML) is a challenging cancer in terms of achieving and maintaining long‐duration remissions. Many novel therapies have been added to the standard regimen (combining cytarabine and anthracycline “7 + 3”) to achieve such goals.… read more here.
Keywords: myeloid leukemia; kit; cytarabine; acute myeloid ... See more keywords
Clofarabine, cytarabine, and mitoxantrone in refractory/relapsed acute myeloid leukemia: High response rates and effective bridge to allogeneic hematopoietic stem cell transplantation
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DOI: 10.1002/cam4.2865
Abstract: Clofarabine is active in refractory/relapsed acute myeloid leukemia (AML). In this phase 2 study, we treated 18‐ to 65‐year‐old AML patients refractory to first‐line 3 + 7 daunorubicin/cytarabine induction or relapsing after 3 + 7… read more here.
Keywords: allo hsct; relapsed acute; clofarabine; refractory relapsed ... See more keywords
The impact of SAMHD1 expression and mutation status in mantle cell lymphoma: An analysis of the MCL Younger and Elderly trial
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DOI: 10.1002/ijc.33202
Abstract: The sterile alpha motif and histidine‐aspartic domain‐containing protein 1 (SAMHD1) has been demonstrated to predict the response to high‐dose cytarabine consolidation treatment in acute myeloid leukemia patients. Here, we evaluated SAMHD1 as potential biomarker for… read more here.
Keywords: samhd1 expression; cytarabine; expression; cell ... See more keywords
Exploring the possible mitoprotective and neuroprotective potency of thymoquinone, betanin, and vitamin D against cytarabine‐induced mitochondrial impairment and neurotoxicity in rats' brain
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DOI: 10.1002/jbt.23256
Abstract: It has been suggested that cytarabine (Ara‐C) induces toxicity via mitochondrial dysfunction and oxidative stress. Therefore, we hypothesized that mitochondrial protective agents and antioxidants can reduce cytarabine‐induced neurotoxicity. For this purpose, 48 male Wistar rats… read more here.
Keywords: brain; group; cytarabine; thymoquinone ... See more keywords
Antibiotic use during cytarabine consolidation in acute myeloid leukemia
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DOI: 10.1007/s00277-020-04238-5
Abstract: Acute myeloid leukemia (AML) patients undergoing consolidation chemotherapy with intermediate or high-dose cytarabine (IDAC/HiDAC) are often placed on prophylactic antibacterials. This practice is largely based on the benefits of prophylaxis (PPX) during induction chemotherapy. However,… read more here.
Keywords: idac hidac; consolidation; myeloid leukemia; cytarabine ... See more keywords
Persistent cytarabine and daunorubicin exposure after administration of novel liposomal formulation CPX-351: population pharmacokinetic assessment
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DOI: 10.1007/s00280-017-3484-5
Abstract: PurposeCPX-351 is a novel liposomal formulation of cytarabine and daunorubicin which has recently been FDA approved for treatment of acute myeloid leukemia (AML). The current study investigated the pharmacokinetics (PK) of this liposomal formulation.MethodsCPX-351 PK… read more here.
Keywords: liposomal formulation; cytarabine; pharmacology; cytarabine daunorubicin ... See more keywords
Nanoscale chemical imaging of individual chemotherapeutic cytarabine-loaded liposomal nanocarriers
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DOI: 10.1007/s12274-018-2202-x
Abstract: Dosage of chemotherapeutic drugs is a tradeoff between efficacy and side-effects. Liposomes are nanocarriers that increase therapy efficacy and minimize side-effects by delivering otherwise difficult to administer therapeutics with improved efficiency and selectivity. Still, variabilities… read more here.
Keywords: nanoscale chemical; chemical imaging; drug; cytarabine ... See more keywords
Assessment of graphite electrode on the removal of anticancer drug cytarabine via indirect electrochemical oxidation process: Kinetics & pathway study.
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DOI: 10.1016/j.chemosphere.2019.125456
Abstract: In this paper degradation of cytarabine drug has been studied through electrochemical oxidation process by using graphite electrode. The performance of graphite electrode on the degradation of cytarabine was evaluated by investigating the effects of… read more here.
Keywords: degradation; graphite electrode; electrochemical oxidation; cytarabine ... See more keywords
Autophagy is an important event for low-dose cytarabine treatment in acute myeloid leukemia cells.
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DOI: 10.1016/j.leukres.2017.06.007
Abstract: Cytarabine (Ara-c) has been an important agent in acute myeloid leukemia (AML) treatment for more than 40 years. While, the mechanisms underlying low dose cytarabine (LD Ara-c) is poorly understood. In this study, we investigated… read more here.
Keywords: low dose; myeloid leukemia; treatment; dose cytarabine ... See more keywords
In vitro anti-leukemic assessment and sustained release behaviour of cytarabine loaded biodegradable polymer based nanoparticles.
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DOI: 10.1016/j.lfs.2020.118971
Abstract: AIMS The study aimed to develop, characterize, and evaluate poly (ɛ-caprolactone) (PCL) based nanoparticles for the sustained release behaviour of cytarabine and to investigate the in vitro anti-cancer influence on KG-1 leukemic cell line. MATERIALS… read more here.
Keywords: based nanoparticles; release behaviour; cytarabine loaded; sustained release ... See more keywords
SAMHD1 is a biomarker for cytarabine response and a therapeutic target in acute myeloid leukemia
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DOI: 10.1038/nm.4255
Abstract: The nucleoside analog cytarabine (Ara-C) is an essential component of primary and salvage chemotherapy regimens for acute myeloid leukemia (AML). After cellular uptake, Ara-C is converted into its therapeutically active triphosphate metabolite, Ara-CTP, which exerts… read more here.
Keywords: samhd1; response; myeloid leukemia; ara ... See more keywords