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   Articles with "cytidine" as a keyword



Crystal structure of Arabidopsis thaliana cytidine deaminase.

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recommendations! Published in 2020 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2020.06.084

Abstract: Cytidine deaminase (CDA) catalyzes the (deoxy)cytidine deamination to (deoxy)uridine, which involves in the catabolic and salvage pathways of pyrimidine nucleotides in plants. CDA serves as a prototype of the cytidine deaminase superfamily that contains a… read more here.

Keywords: crystal structure; structure arabidopsis; arabidopsis thaliana; cytidine ... See more keywords

Cytidine Diphosphoramidate Kinase: An Enzyme Required for the Biosynthesis of the O-Methyl Phosphoramidate Modification in the Capsular Polysaccharides of Campylobacter jejuni.

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recommendations! Published in 2018 at "Biochemistry"

DOI: 10.1021/acs.biochem.8b00279

Abstract: Campylobacter jejuni, a leading cause of gastroenteritis, produces a capsular polysaccharide that is derivatized with a unique O-methyl phosphoramidate (MeOPN) modification. This modification contributes to serum resistance and invasion of epithelial cells. Previously, the first… read more here.

Keywords: campylobacter jejuni; diphosphoramidate; kinase; cytidine diphosphoramidate ... See more keywords

Multivariate Modular Metabolic Engineering for the Enhanced Biosynthesis of Cytidine in Bacillus subtilis.

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recommendations! Published in 2025 at "Journal of agricultural and food chemistry"

DOI: 10.1021/acs.jafc.5c01391

Abstract: As a pyrimidine nucleoside, cytidine is widely used in the medicine and food fields. Therefore, it is important to construct a microbial cell factory for efficient and sustainable cytidine production. Here, we perform modular metabolic… read more here.

Keywords: metabolic engineering; cytidine; modular metabolic; cytidine titer ... See more keywords

Modeling pK Shift in DNA Triplexes Containing Locked Nucleic Acids

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recommendations! Published in 2018 at "Journal of chemical information and modeling"

DOI: 10.1021/acs.jcim.7b00741

Abstract: The protonation states for nucleic acid bases are difficult to assess experimentally. In the context of DNA triplex, the protonation state of cytidine in the third strand is particularly important, because it needs to be… read more here.

Keywords: dna; dna triplex; cytidine; third strand ... See more keywords

Development and Comparison of 4-Thiouridine to Cytidine Base Conversion Reaction

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recommendations! Published in 2024 at "ACS Omega"

DOI: 10.1021/acsomega.3c08516

Abstract: To study transcriptome dynamics without harming cells, it is essential to convert chemical bases. 4-Thiouridine (4sU) is a biocompatible uridine analogue that can be converted into a cytidine analogue. Although several reactions can convert 4sU… read more here.

Keywords: reaction; analogue; conversion; cytidine ... See more keywords

Inactivation of cytidine triphosphate synthase 1 prevents fatal auto-immunity in mice

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recommendations! Published in 2024 at "Nature Communications"

DOI: 10.1038/s41467-024-45805-y

Abstract: De novo synthesis of the pyrimidine, cytidine triphosphate (CTP), is crucial for DNA/RNA metabolism and depends on the CTP synthetases, CTPS1 and −2. Partial CTPS1 deficiency in humans has previously been shown to lead to… read more here.

Keywords: immunity; ctps1; cytidine; inactivation ... See more keywords

Characterization of uridine-cytidine kinase like-1 nucleoside kinase activity and its role in tumor growth

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recommendations! Published in 2022 at "Biochemical Journal"

DOI: 10.1042/bcj20210770

Abstract: Uridine-cytidine kinase like-1 (UCKL-1) is a largely uncharacterized protein with high sequence similarity to other uridine-cytidine kinases (UCKs). UCKs play an important role in the pyrimidine salvage pathway, catalyzing the phosphorylation of uridine and cytidine… read more here.

Keywords: cytidine; uridine cytidine; tumor growth; kinase ... See more keywords

Accelerated discovery and miniaturization of novel single-stranded cytidine deaminases

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recommendations! Published in 2024 at "Nucleic Acids Research"

DOI: 10.1093/nar/gkae800

Abstract: Abstract Cytidine base editors (CBEs) hold significant potential in genetic disease treatment and in breeding superior traits into animals. However, their large protein sizes limit their delivery by adeno-associated virus (AAV), given its packing capacity… read more here.

Keywords: editing efficiency; miniaturization; cytidine; accelerated discovery ... See more keywords

Self-organization of parS centromeres by the ParB CTP hydrolase

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recommendations! Published in 2019 at "Science"

DOI: 10.1126/science.aay3965

Abstract: CTP hydrolysis organizes chromosomes The bacterial DNA parS centromere recruits the ParB protein to the bacterial chromosome. Soh et al. found that the widespread family of ParB proteins not only bind DNA but also bind… read more here.

Keywords: parb protein; parb ctp; ctp; cytidine ... See more keywords

The cytidine deaminase APOBEC3G contributes to cancer mutagenesis and clonal evolution in bladder cancer.

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recommendations! Published in 2022 at "Cancer research"

DOI: 10.1158/0008-5472.can-22-2912

Abstract: Mutagenic processes leave distinct signatures in cancer genomes. The mutational signatures attributed to APOBEC3 cytidine deaminases are pervasive in human cancers. However, data linking individual APOBEC3 proteins to cancer mutagenesis in vivo are limited. Here,… read more here.

Keywords: cytidine; cancer mutagenesis; apobec3g; bladder cancer ... See more keywords

Cytidine Alleviates Dyslipidemia and Modulates the Gut Microbiota Composition in ob/ob Mice

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recommendations! Published in 2023 at "Nutrients"

DOI: 10.3390/nu15051147

Abstract: Cytidine and uridine are endogenous metabolites in the pyrimidine metabolism pathway, and cytidine is a substrate that can be metabolized into uridine via cytidine deaminase. Uridine has been widely reported to be effective in regulating… read more here.

Keywords: metabolism; gut microbiota; cytidine; composition mice ... See more keywords