Activation-induced cytidine deaminase: in sickness and in health
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cancer Research and Clinical Oncology"
DOI: 10.1007/s00432-020-03348-x
Abstract: Activation Induced cytidine Deaminase (AID) is an essential enzyme of the adaptive immune system. Its canonical activity is restricted to B lymphocytes, playing an essential role in the diversification of antibodies by enhancing specificity and… read more here.
Keywords: activation induced; aid; induced cytidine; cytidine deaminase ... See more keywords
Multiplex genome editing using a dCas9-cytidine deaminase fusion in Streptomyces
Sign Up to like & getrecommendations! Published in 2019 at "Science China Life Sciences"
DOI: 10.1007/s11427-019-1559-y
Abstract: CRISPR/Cas-mediated genome editing has greatly facilitated the study of gene function in Streptomyces. However, it could not be efficiently employed in streptomycetes with low homologous recombination (HR) ability. Here, a deaminase-assisted base editor dCas9-CDA-ULstr was… read more here.
Keywords: genome editing; cda ulstr; base; dcas9 cda ... See more keywords
Crystal structure of Arabidopsis thaliana cytidine deaminase.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.06.084
Abstract: Cytidine deaminase (CDA) catalyzes the (deoxy)cytidine deamination to (deoxy)uridine, which involves in the catabolic and salvage pathways of pyrimidine nucleotides in plants. CDA serves as a prototype of the cytidine deaminase superfamily that contains a… read more here.
Keywords: crystal structure; structure arabidopsis; arabidopsis thaliana; cytidine ... See more keywords
Cytidine Deaminase Activity Assessment to Select Perioperative Chemotherapy Regimen in Localized Bladder Cancer
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Genitourinary Cancer"
DOI: 10.1016/j.clgc.2017.01.017
Abstract: The optimal perioperative chemotherapy regimen in localized bladder cancer is still unknown. The cisplatin-gemcitabine regimen is a reasonable alternative to accelerated methotrexate, vincristine, cisplatin, and adriamycin in this setting in terms of efficacy. Gemcitabine is… read more here.
Keywords: chemotherapy regimen; regimen localized; perioperative chemotherapy; cancer ... See more keywords
HomA and HomB, outer membrane proteins of Helicobacter pylori down-regulate activation-induced cytidine deaminase (AID) and Ig switch germline transcription and thereby affect class switch recombination (CSR) of Ig genes in human B-cells.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular immunology"
DOI: 10.1016/j.molimm.2021.12.014
Abstract: H. pylori is one of the major causes of chronic gastritis, peptic ulcer disease (PUD), gastric mucosa-associated lymphoid tissue lymphoma (MALT) and gastric carcinoma. H. pylori toxin VacA is responsible for host cell apoptosis, whereas… read more here.
Keywords: deaminase aid; switch; activation induced; aid ... See more keywords
Cytidine deaminase deficiency impairs sister chromatid disjunction by decreasing PARP-1 activity
Sign Up to like & getrecommendations! Published in 2017 at "Cell Cycle"
DOI: 10.1080/15384101.2017.1317413
Abstract: ABSTRACT Bloom Syndrome (BS) is a rare genetic disease characterized by high levels of chromosomal instability and an increase in cancer risk. Cytidine deaminase (CDA) expression is downregulated in BS cells, leading to an excess… read more here.
Keywords: chromatid disjunction; sister chromatid; parp activity; cytidine deaminase ... See more keywords
Involvement of activation induced cytidine deaminase in malignant B-cells expressing two distinct M-components as an etiology of biclonal gammopathy
Sign Up to like & getrecommendations! Published in 2022 at "Medicine"
DOI: 10.1097/md.0000000000032260
Abstract: Biclonal gammopathy (BG) is a rare phenomenon in which 2 M proteins are detected in the same patient, with 2 major hypotheses regarding its etiology. One potential explanation is that completely different malignant B-cell clones… read more here.
Keywords: induced cytidine; etiology; biclonal gammopathy; activation induced ... See more keywords
Identification of Editable Sites, Spacer Oligonucleotide Design, and Generation of the Gene-Targeting CRISPR-nCas9 Plasmid for Gene Disruption in Staphylococcus aureus Using the CRISPR-nCas9 and Cytidine Deaminase System.
Sign Up to like & getrecommendations! Published in 2023 at "Cold Spring Harbor protocols"
DOI: 10.1101/pdb.prot107924
Abstract: Methods for gene disruption are essential for functional genomics, and there are multiple approaches for altering gene function in bacteria. One of these methods involves introducing a premature stop codon in a gene of interest,… read more here.
Keywords: ncas9 cytidine; gene targeting; cytidine deaminase; gene ... See more keywords
Intracellular Cytidine Deaminase Regulates Gemcitabine Metabolism in Pancreatic Cancer Cell Lines
Sign Up to like & getrecommendations! Published in 2019 at "Drug Metabolism and Disposition"
DOI: 10.1124/dmd.119.089334
Abstract: Cytidine deaminase (CDA) is a determinant of in vivo gemcitabine elimination kinetics and cellular toxicity. The impact of CDA activity in pancreatic ductal adenocarcinoma (PDAC) cell lines has not been elucidated. We hypothesized that CDA… read more here.
Keywords: cda; gemcitabine; cell lines; mia paca ... See more keywords
Abstract A49: Induction of the lymphomagenic enzyme activation-induced cytidine deaminase (AID) upon in vitro exposure to phenylurea herbicides
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Prevention Research"
DOI: 10.1158/1940-6215.envcaprev19-a49
Abstract: Many studies have drawn associations between pesticide exposures and lymphomagenesis, both in occupational settings and in the general population. The specific compounds responsible for an increased risk of non-Hodgkin lymphoma in pesticide-exposed individuals have not… read more here.
Keywords: activation induced; aid; phenylurea herbicides; induced cytidine ... See more keywords
The APOBEC3B cytidine deaminase is an adenovirus restriction factor
Sign Up to like & getrecommendations! Published in 2023 at "PLOS Pathogens"
DOI: 10.1371/journal.ppat.1011156
Abstract: Human adenoviruses (HAdVs) are a large family of DNA viruses counting more than a hundred strains divided into seven species (A to G). HAdVs induce respiratory tract infections, gastroenteritis and conjunctivitis. APOBEC3B is a cytidine… read more here.
Keywords: apobec3b; apobec3b cytidine; deaminase; cytidine deaminase ... See more keywords