Expanding C–T base editing toolkit with diversified cytidine deaminases
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DOI: 10.1038/s41467-019-11562-6
Abstract: Base editing tools for cytosine to thymine (C–T) conversion enable genome manipulation at single base-pair resolution with high efficiency. Available base editors (BEs) for C–T conversion (CBEs) have restricted editing scopes and nonnegligible off-target effects,… read more here.
Keywords: base editing; editing toolkit; base editors; base ... See more keywords
Abstract 3366: APOBEC3 family of cytidine deaminases in sensitizing triple-negative breast cancer cells to cisplatin and carboplatin
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DOI: 10.1158/1538-7445.am2018-3366
Abstract: Cisplatin is a DNA damaging chemotherapeutic which forms interstrand crosslinks (ICL) and intrastrand adducts that induce replication fork collapse and lead to apoptosis. These adduct sites can be repaired through several repair pathways, the most… read more here.
Keywords: cancer; cisplatin carboplatin; cytidine deaminases; family cytidine ... See more keywords
Clearing of Foreign Episomal DNA from Human Cells by CRISPRa-Mediated Activation of Cytidine Deaminases
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DOI: 10.3390/ijms21186865
Abstract: Restriction of foreign DNA is a fundamental defense mechanism required for maintaining genomic stability and proper function of mammalian cells. APOBEC cytidine deaminases are crucial effector molecules involved in clearing pathogenic DNA of viruses and… read more here.
Keywords: crispra mediated; dna; crispra; cytidine deaminases ... See more keywords