An Efficient Synthetic Method for N-Alkylcytisines
Sign Up to like & getrecommendations! Published in 2019 at "Chemistry of Natural Compounds"
DOI: 10.1007/s10600-019-02703-w
Abstract: Cytisine and its derivatives are attractive to many researchers because of their broad spectra of biological activity, e.g., spasmolytic, insecticidal, cholinergic, analgesic, etc. [1–7]. Therefore, the alkaloid cytisine and its derivatives are promising compounds for… read more here.
Keywords: method; efficient synthetic; cytisine; synthetic method ... See more keywords
The effectiveness, safety and cost-effectiveness of cytisine versus varenicline for smoking cessation in an Australian population: a study protocol for a randomized controlled non-inferiority trial.
Sign Up to like & getrecommendations! Published in 2018 at "Addiction"
DOI: 10.1111/add.14541
Abstract: BACKGROUND AND AIMS Smoking cessation medications are effective, but often underutilized because of costs and side effects. Cytisine is a plant-based smoking cessation medication with more than 50 years of use in central and eastern Europe.… read more here.
Keywords: safety cost; cytisine; smoking cessation; cessation ... See more keywords
Cytisine - From the Past to the Future.
Sign Up to like & getrecommendations! Published in 2018 at "Current pharmaceutical design"
DOI: 10.2174/1381612825666181123124733
Abstract: INTRODUCTION Neuronal nicotinic acetylcholine receptors are ligand-gated ion channel receptors, distributed throughout central nervous system, as well as in peripheral ganglia and some non-neuronal cells. Cytisine, a qulinolizidine alkaloid, could be considered a high affinity… read more here.
Keywords: past future; cytisine; treatment; cytisine past ... See more keywords
Cytisine Exerts an Anti-Epileptic Effect via α7nAChRs in a Rat Model of Temporal Lobe Epilepsy
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.706225
Abstract: Background and Purpose: Temporal lobe epilepsy (TLE) is a common chronic neurological disease that is often invulnerable to anti-epileptic drugs. Increasing data have demonstrated that acetylcholine (ACh) and cholinergic neurotransmission are involved in the pathophysiology… read more here.
Keywords: lobe epilepsy; cytisine; anti epileptic; temporal lobe ... See more keywords
Efficacy and Safety of Cytisine in Combination with a Community Pharmacists’ Counselling for Smoking Cessation in Thailand: A Randomized Double-Blinded Placebo-Controlled Trial
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Environmental Research and Public Health"
DOI: 10.3390/ijerph192013358
Abstract: Background: Cytisine is a prospective pharmacological alternative for community pharmacy smoking cessation services. However, it has not yet been licensed because of a lack of efficacy and safety information in Thailand. Objective: The aim of… read more here.
Keywords: cytisine; smoking cessation; placebo; community ... See more keywords
Spray-Dried Cytisine-Loaded Matrices: Development of Transbuccal Sustained-Release Tablets as a Promising Tool in Smoking Cessation Therapy
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14081583
Abstract: Cytisine (CYT) has emerged as a promising molecule to treat nicotine addiction, since it acts as a partial agonist of nicotinic acetylcholine receptors. However, its unfavorable pharmacokinetic properties lead to multiple administrations per day, reducing… read more here.
Keywords: cytisine; dried cytisine; spray dried; cytisine loaded ... See more keywords
Synthesis, Properties and Spatial Structure of 4-[(3,5-Dimethyl-1,2-oxazol-4-yl)sulfonyl]cytisine
Sign Up to like & getrecommendations! Published in 2022 at "Plants"
DOI: 10.3390/plants12010137
Abstract: This article has studied the synthesis of a new derivative of the known alkaloid cytisine contained in the seeds of plants of Cytisus laburnum L. and Thermopsis lanceolata R.Br., both of the Lugiminosae family. The… read more here.
Keywords: spatial structure; structure; cytisine; dimethyl oxazol ... See more keywords
Cytisine induces apoptosis of HepG2 cells.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular medicine reports"
DOI: 10.3892/mmr.2017.6991
Abstract: Cytisine is a quinolizidine alkaloid, which has been reported to be among the major bioactive components of Sophora alopecuraides L. Quinolizidine alkaloids have previously been demonstrated to inhibit the proliferation of several types of tumor cells.… read more here.
Keywords: cytisine; hepg2 cells; caspase; apoptosis hepg2 ... See more keywords