In vitro inhibition and reversal of Plasmodium falciparum cytoadherence to endothelium by monoclonal antibodies to ICAM-1 and CD36
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DOI: 10.1186/s12936-017-1930-9
Abstract: BackgroundSequestration of parasitized red blood cells from the peripheral circulation during an infection with Plasmodium falciparum is caused by an interaction between the parasite protein PfEMP1 and receptors on the surface of host endothelial cells,… read more here.
Keywords: monoclonal antibodies; plasmodium falciparum; cytoadherence; icam cd36 ... See more keywords
Distinct features of the host-parasite interactions between nonadherent and adherent Trichomonas vaginalis isolates
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DOI: 10.1371/journal.pntd.0011016
Abstract: Cytoadherence of Trichomonas vaginalis to human vaginal epithelial cells (hVECs) was previously shown to involve surface lipoglycans and several reputed adhesins on the parasite. Herein, we report some new observations on the host-parasite interactions of… read more here.
Keywords: cytoadherence; parasite interactions; host parasite; isolate ... See more keywords
Computational Insights into the Interaction between Cytoadherence Receptor gC1qR and the DBLβ12 Domain of a Plasmodium falciparum PfEMP1 Ligand
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DOI: 10.3390/life11090993
Abstract: Human receptor gC1qR is a 32 kD protein that mediates the cytoadherence of Plasmodium falciparum-infected erythrocytes (IEs) to human brain microvascular endothelial cells (HBMEC) and platelets. The cytoadherence of IEs to gC1qR has been associated… read more here.
Keywords: dbl domain; gc1qr; receptor gc1qr; cytoadherence ... See more keywords
In Silico Prediction of Plasmodium falciparum Cytoadherence Inhibitors That Disrupt Interaction between gC1qR-DBLβ12 Complex
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DOI: 10.3390/ph15060691
Abstract: Malaria causes about half a million deaths per year, mainly in children below 5 years of age. Cytoadherence of Plasmodium falciparum infected erythrocytes in brain and placenta has been linked to severe malaria and malarial… read more here.
Keywords: interaction; cytoadherence; falciparum; gc1qr dbl ... See more keywords