Biochemical pathway for the biosynthesis of the CuA center in bacterial cytochrome c oxidase
Sign Up to like & getrecommendations! Published in 2019 at "FEBS Letters"
DOI: 10.1002/1873-3468.13587
Abstract: The di‐copper center CuA is an essential metal cofactor in cytochrome oxidase (Cox) of mitochondria and many prokaryotes, mediating one‐electron transfer from cytochrome c to the site for oxygen reduction. CuA is located in subunit… read more here.
Keywords: cytochrome oxidase; cu2; center; coxb ... See more keywords
Cytochrome c oxidase biogenesis - from translation to early assembly of the core subunit COX1.
Sign Up to like & getrecommendations! Published in 2023 at "FEBS letters"
DOI: 10.1002/1873-3468.14671
Abstract: Mitochondria are the power houses of the cell as they produce the majority of ATP with their OXPHOS (oxidative phosphorylation) machinery. The OXPHOS system is composed of the F1 Fo ATP-synthase and four mitochondrial respiratory… read more here.
Keywords: oxidase biogenesis; core; cytochrome oxidase; translation ... See more keywords
COX6A2 variants cause a muscle‐specific cytochrome c oxidase deficiency
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Neurology"
DOI: 10.1002/ana.25517
Abstract: Cytochrome c oxidase (COX) deficiency is a major mitochondrial respiratory chain defect that has vast genetic and phenotypic heterogeneity. This study aims to identify novel causative genes of COX deficiency with only striated muscle–specific symptoms. read more here.
Keywords: cytochrome oxidase; deficiency; muscle specific; cox6a2 variants ... See more keywords
Simulating the slow to fast switch in cytochrome c oxidase catalysis by introducing a loop flip near the enzyme's cytochrome c (substrate) binding site
Sign Up to like & getrecommendations! Published in 2017 at "Biotechnology and Applied Biochemistry"
DOI: 10.1002/bab.1526
Abstract: The mitochondrial enzyme cytochrome c oxidase catalyzes the reduction of molecular oxygen in the critical step of oxidative phosphorylation that links the oxidation of food consumed to ATP production in cells. The enzyme catalyzes the… read more here.
Keywords: cytochrome oxidase; cytochrome; cox; enzyme cytochrome ... See more keywords
Regional distribution of cytochrome c oxidase activity and copper in sclerotic hippocampi of epilepsy patients
Sign Up to like & getrecommendations! Published in 2020 at "Brain and Behavior"
DOI: 10.1002/brb3.1986
Abstract: Disruption of copper homeostasis and dysfunction of mitochondria have been documented in sclerotic hippocampi (HS) of patients with mesial temporal lobe epilepsy (mTLE). However, a potential link between these pathological changes has not been tackled… read more here.
Keywords: epilepsy; cytochrome oxidase; copper; regional distribution ... See more keywords
Structure and molecular evolution of the barcode fragment of cytochrome oxidase I (COI) in Macrocheles (Acari: Mesostigmata: Macrochelidae)
Sign Up to like & getrecommendations! Published in 2022 at "Ecology and Evolution"
DOI: 10.1002/ece3.9553
Abstract: Abstract Consisting of approximately 320 species, Macrocheles is the most widely distributed genus in the family Macrochelidae. Though some studies have focused on the description of Macrochelidae using molecular techniques (e.g., RAPD) and sequencing of… read more here.
Keywords: structure molecular; molecular evolution; cytochrome oxidase; structure ... See more keywords
Identification of a novel homozygous synthesis of cytochrome c oxidase 2 variant in siblings with early‐onset axonal Charcot‐Marie‐Tooth disease
Sign Up to like & getrecommendations! Published in 2022 at "Human Mutation"
DOI: 10.1002/humu.24338
Abstract: The synthesis of cytochrome c oxidase 2 (SCO2) gene encodes for a mitochondrial located metallochaperone essential for the synthesis of the cytochrome c oxidase (COX) subunit 2. Recessive mutations in SCO2 have been reported in… read more here.
Keywords: cytochrome oxidase; synthesis cytochrome; identification novel;
A Method to Detect Cytochrome c Oxidase Activity and Mitochondrial Proteins in Oligodendrocytes.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9072-6_19
Abstract: Cytochrome c oxidase or mitochondrial respiratory chain complex IV is where over 90% of oxygen is consumed. The relationship between complex IV activity and mitochondrial proteins, which provides a guide to understanding the mechanisms in… read more here.
Keywords: mitochondrial proteins; cytochrome oxidase; histochemistry; activity mitochondrial ... See more keywords
Broadband NIRS Cerebral Cytochrome-C-Oxidase Response to Anoxia Before and After Hypoxic-Ischaemic Injury in Piglets
Sign Up to like & getrecommendations! Published in 2018 at "Advances in Experimental Medicine and Biology"
DOI: 10.1007/978-3-319-91287-5_24
Abstract: Perinatal hypoxic ischaemic (HI) encephalopathy is associated with severe neurodevelopment problems and mortality. This study uses broadband continuous-wave near-infrared spectroscopy (NIRS) to assess the early changes in cerebral oxygenation and metabolism after HI injury in… read more here.
Keywords: cytochrome oxidase; hypoxic ischaemic; response anoxia; spectroscopy ... See more keywords
Synthesis of cytochrome c oxidase 1 (SCO1) inhibits insulin sensitivity by decreasing copper levels in adipocytes.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.06.124
Abstract: Dysregulation of insulin signaling leads to type 2 diabetes mellitus (T2DM) and other metabolic disorders. Obesity is an important contributor to insulin resistance, and although the understanding of this relationship has improved in recent years,… read more here.
Keywords: sco1; cytochrome oxidase; copper; insulin sensitivity ... See more keywords
Rationally designed molecules for resurgence of cyanide mitigated cytochrome c oxidase activity.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2018.10.045
Abstract: Cytochrome c oxidase (CcOX) containing binuclear heme a3-Cu B centre (BNC) mechanises the process of electron transfer in the last phase of cellular respiration. The molecular modelling based structural analysis of CcOX - heme a3-Cu… read more here.
Keywords: cytochrome oxidase; compound; rationally designed; cyanide ... See more keywords