Structural comparison of the cytochrome P450 enzymes CYP106A1 and CYP106A2 provides insight into their differences in steroid conversion
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14502
Abstract: Understanding the structural basis of the selectivity of steroid hydroxylation requires detailed structural and functional investigations on various steroid hydroxylases with different selectivities, such as the bacterial cytochrome P450 enzymes. Here, the crystal structure of… read more here.
Keywords: p450; cytochrome p450; p450 enzymes; structural comparison ... See more keywords
Genome-wide and expression-profiling analyses of the cytochrome P450 genes in Tenebrionidea.
Sign Up to like & getrecommendations! Published in 2022 at "Archives of insect biochemistry and physiology"
DOI: 10.1002/arch.21954
Abstract: Cytochrome P450 monooxygenases (CYPs) are present in almost all areas of the tree of life. As one of the largest and most diverse superfamilies of multifunctional enzymes, they play important roles in the metabolism of… read more here.
Keywords: cyp genes; genome wide; expression; cytochrome p450 ... See more keywords
Oxygenation cascade analysis in conversion of n‐octane catalyzed by cytochrome P450 CYP102A3 mutants at the P331 site
Sign Up to like & getrecommendations! Published in 2017 at "Biotechnology and Applied Biochemistry"
DOI: 10.1002/bab.1472
Abstract: To improve the hydroxylation efficiency of cytochrome P450 CYP102A3 to substrate n‐octane, a previously reported triple‐mutant F88V/S188Q/A330V with altered regioselectivity was selected and site‐saturation mutagenesis was performed at its P331 site, which is adjacent to… read more here.
Keywords: octane; conversion; cyp102a3; cytochrome p450 ... See more keywords
Minimization of the Thiolactomycin Biosynthetic Pathway Reveals that the Cytochrome P450 Enzyme TlmF Is Required for Five‐Membered Thiolactone Ring Formation
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DOI: 10.1002/cbic.201700090
Abstract: Thiolactomycin (TLM) belongs to a class of rare and unique thiotetronate antibiotics that inhibit bacterial fatty acid synthesis. Although this group of natural product antibiotics was first discovered over 30 years ago, the study of… read more here.
Keywords: thiolactomycin; thiolactone ring; membered thiolactone; thiolactone ... See more keywords
Coexpression of 5‐Aminolevulinic Acid Synthase Gene Facilitates Heterologous Production of Thermostable Cytochrome P450, CYP119, in Holo Form in Escherichia coli
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DOI: 10.1002/cbic.201800331
Abstract: Cytochrome P450 enzymes are heme‐containing monooxygenases that exhibit potential as biocatalysts for practical applications. The Escherichia coli expression system is frequently used for biocatalyst production; however, heterologous production of hemeproteins in their holo form is… read more here.
Keywords: coexpression; holo form; production; heterologous production ... See more keywords
Design, Synthesis and In Vivo Fluorescence Imaging Study of a Cytochrome P450 1B1 Targeted NIR Probe Containing a Chelator Moiety
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DOI: 10.1002/cbic.202200268
Abstract: Cytochrome P450 (CYP) 1B1 has been found to be overexpressed specifically in tumor tissues at an early stage, which makes it a potential cancer biomarker for molecular imaging. Multimodal imaging combines different imaging modalities and… read more here.
Keywords: chelator; chelator moiety; cytochrome p450; probe ... See more keywords
Biocatalytical Asymmetric Sulfoxidation by Identifying Cytochrome P450 from Parvibaculum Lavamentivorans DS‐1
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DOI: 10.1002/cctc.201801139
Abstract: Cytochrome P450 monooxygenases (P450s) catalyzed asymmetric sulfoxidation represents a green route for the synthesis of valuable enantiopure sulfoxides, which are potentially interesting synthons in synthetic and pharmaceutical chemistry. Here the potential P450 and redox partner… read more here.
Keywords: parvibaculum lavamentivorans; biocatalytical asymmetric; asymmetric sulfoxidation; p450 ... See more keywords
Chemogenomic Active Learning's Domain of Applicability on Small, Sparse qHTS Matrices: A Study Using Cytochrome P450 and Nuclear Hormone Receptor Families
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DOI: 10.1002/cmdc.201700677
Abstract: Computational models for predicting the activity of small molecules against targets are now routinely developed and used in academia and industry, partially due to public bioactivity databases. While models based on bigger datasets are the… read more here.
Keywords: active learning; hormone receptor; nuclear hormone; cytochrome p450 ... See more keywords
Evaluation of the Cytochrome P450 3A and P-glycoprotein Drug-Drug Interaction Potential of Futibatinib.
Sign Up to like & getrecommendations! Published in 2023 at "Clinical pharmacology in drug development"
DOI: 10.1002/cpdd.1259
Abstract: Futibatinib, a selective, irreversible fibroblast growth factor receptor 1-4 inhibitor, is being investigated for tumors harboring FGFR aberrations and was recently approved for the treatment of FGFR2 fusion/rearrangement-positive intrahepatic cholangiocarcinoma. In vitro studies identified cytochrome… read more here.
Keywords: cyp3a; plasma concentration; drug drug; cytochrome p450 ... See more keywords
Pharmacokinetic Effects of Isavuconazole Coadministration With the Cytochrome P450 Enzyme Substrates Bupropion, Repaglinide, Caffeine, Dextromethorphan, and Methadone in Healthy Subjects
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.281
Abstract: This report describes phase 1 clinical trials performed to assess interactions of oral isavuconazole at the clinically targeted dose (200 mg, administered as isavuconazonium sulfate 372 mg, 3 times a day for 2 days; 200… read more here.
Keywords: auc reduced; methadone; auc; substrates bupropion ... See more keywords
Liquid Biopsy for Patient Characterization in Cardiovascular Disease: Verification against Markers of Cytochrome P450 and P‐Glycoprotein Activities
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.2576
Abstract: Precision dosing strategies require accounting for between‐patient variability in pharmacokinetics together with subsequent pharmacodynamic differences. Liquid biopsy is a valuable new approach to diagnose disease prior to the appearance of clinical signs and symptoms, potentially… read more here.
Keywords: cardiovascular disease; expression; cytochrome p450; biopsy ... See more keywords