Genome-wide identification and expression profiling revealed tissue-specific inducible expression of cytochrome P450s conferring cadmium tolerance in the Pacific oyster, Crassostrea gigas
Sign Up to like & getrecommendations! Published in 2021 at "Aquaculture Reports"
DOI: 10.1016/j.aqrep.2020.100582
Abstract: Abstract Cytochrome P450s (CYPs) are present in almost all organisms and play critical roles in metabolism of endogenous substrates and detoxification of xenobiotic compounds. Oysters are a group of bivalves that are important in marine… read more here.
Keywords: expression; gigas; cytochrome p450s; pacific oyster ... See more keywords
Discovery and Engineering of Cytochrome P450s for Terpenoid Biosynthesis.
Sign Up to like & getrecommendations! Published in 2019 at "Trends in biotechnology"
DOI: 10.1016/j.tibtech.2018.11.008
Abstract: Terpenoids represent 60% of known natural products, including many drugs and drug candidates, and their biosynthesis is attracting great interest. However, the unknown cytochrome P450s (CYPs) in terpenoid biosynthetic pathways make the heterologous production of… read more here.
Keywords: terpenoid biosynthesis; discovery engineering; biosynthesis; cytochrome p450s ... See more keywords
Metabolites of Cannabigerol Generated by Human Cytochrome P450s Are Bioactive.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemistry"
DOI: 10.1021/acs.biochem.2c00383
Abstract: The phytocannabinoid cannabigerol (CBG) is the central biosynthetic precursor to many cannabinoids, including Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD). Though the use of CBG has recently witnessed a widespread surge because of its beneficial health effects… read more here.
Keywords: human cytochrome; cbg; mass spectrometry; cytochrome p450s ... See more keywords
Functional Validation of the Roles of Cytochrome P450s in Tolerance to Thiamethoxam and Imidacloprid in a Field Population of Aphis gossypii.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c04867
Abstract: Field populations of Aphis gossypii (SDR) have evolved high resistance to neonicotinoids, including thiamethoxam and imidacloprid. Synergism bioassays and transcriptomic comparison of the SDR and susceptible (SS) strains revealed that the cytochrome P450s may contribute… read more here.
Keywords: sdr; cytochrome p450s; aphis gossypii; thiamethoxam imidacloprid ... See more keywords
Characterizing Two Cytochrome P450s in Tiacumicin Biosynthesis Reveals Reaction Timing for Tailoring Modifications.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b03100
Abstract: Functions of the tailoring enzymes for the biosynthesis of tiacumicin B (1) have been previously determined. However, the reaction timing remains elusive. Herein, we report the in vitro biochemical characterization of two P450 enzymes TiaP1… read more here.
Keywords: biosynthesis; reaction timing; cytochrome p450s; two cytochrome ... See more keywords
Set of Cytochrome P450s Cooperatively Catalyzes the Synthesis of a Highly Oxidized and Rearranged Diterpene-Class Sordarinane Architecture.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.1c12427
Abstract: Cytochrome P450s are one of the most versatile oxidases that catalyze significant and unique chemical transformations for the construction of complex structural frameworks during natural product biosynthesis. Here, we discovered a set of P450s, including… read more here.
Keywords: sordarinane architecture; p450s; cytochrome p450s; highly oxidized ... See more keywords
Perspective of the Induction of Liver Microsomal Cytochrome P450s by Chemical Compounds
Sign Up to like & getrecommendations! Published in 2022 at "Drug Metabolism and Disposition"
DOI: 10.1124/dmd.122.000891
Abstract: The concept of hepatic induction of drug-metabolizing cytochrome P450s (P450s) by xenobiotics, including therapeutic drugs, was proposed in the early 1960s. A polycyclic aromatic hydrocarbon and phenobarbital have been the two major inducers used to… read more here.
Keywords: cytochrome p450s; induction liver; p450s; perspective induction ... See more keywords
Structural Modeling of Drosophila melanogaster Gut Cytochrome P450s and Docking Comparison of Fruit Fly Gut and Human Cytochrome P450s.
Sign Up to like & getrecommendations! Published in 2022 at "Current drug metabolism"
DOI: 10.2174/1389200223666220511162234
Abstract: Drosophila melanogaster is a prominent model organism in developmental biology research and in studies related to pathophysiological conditions like cancer and Alzheimer's disease. The fruit fly gut contains several cytochrome P450s (CYP450s) which have central… read more here.
Keywords: melanogaster gut; cytochrome p450s; fly gut; melanogaster ... See more keywords
The Impact of the Coronavirus (COVID-19) Infection on the Drug-Metabolizing Enzymes Cytochrome P450s.
Sign Up to like & getrecommendations! Published in 2022 at "Drug metabolism letters"
DOI: 10.2174/1872312815666220331142046
Abstract: Coronaviruses cause disease in human and animals. In 2019 a novel coronavirus was first characterized in Wuhan, China. It causes acute respiratory disease and designated the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or COVID-19.… read more here.
Keywords: covid infection; cytochrome p450s; coronavirus; drug ... See more keywords
Characterization of Insecticide Response-Associated Transcripts in the Colorado Potato Beetle: Relevance of Selected Cytochrome P450s and Clothianidin
Sign Up to like & getrecommendations! Published in 2022 at "Insects"
DOI: 10.3390/insects13060505
Abstract: Simple Summary The Colorado potato beetle is an insect pest that can significantly harm potato crops. Various approaches are available to mitigate its damages including the use of insecticides. Unfortunately, its ability to develop resistance… read more here.
Keywords: colorado potato; insects; cytochrome p450s; insecticide response ... See more keywords
Genome-Wide Analysis of Cytochrome P450s of Alternaria Species: Evolutionary Origin, Family Expansion and Putative Functions
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Fungi"
DOI: 10.3390/jof8040324
Abstract: Cytochrome P450s are a group of monooxygenase enzymes involved in primary, secondary and xenobiotic metabolisms. They have a wide application in the agriculture sector where they could serve as a target for herbicides or fungicides,… read more here.
Keywords: expansion; cytochrome p450s; alternaria; alternaria species ... See more keywords