Cytogenetic abnormalities in systemic mastocytosis: WHO subcategory‐specific incidence and prognostic impact among 348 informative cases
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DOI: 10.1002/ajh.25265
Abstract: The World Health Organization (WHO) system lists five morphological categories of systemic mastocytosis (SM): indolent (ISM), smoldering, SM with an associated hematological neoplasm (SM‐AHN), aggressive (ASM) and mast cell leukemia (MCL). Recent studies have highlighted… read more here.
Keywords: incidence; cytogenetic abnormalities; systemic mastocytosis; abnormal karyotype ... See more keywords
Age and cytogenetic abnormalities☆
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DOI: 10.1016/j.htct.2018.01.004
Abstract: its relationship to cancer. Nat Genet. 2012;44(6):642–50. 5. Sahin E, Depinho RA. Linking functional decline of telomeres, n this issue, the Hematology, Transfusion and Cell Therapy ournal is publishing a paper of Alves et al.… read more here.
Keywords: cytogenetic abnormalities; hematology; onco hematological; age cytogenetic ... See more keywords
Prognostic impact of cytogenetic abnormalities in adult patients with Philadelphia chromosome-negative ALL who underwent an allogeneic transplant
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DOI: 10.1038/s41409-019-0585-2
Abstract: Although cytogenetic abnormalities at diagnosis are recognized as an important prognostic factor in patients with Philadelphia chromosome (Ph)-negative acute lymphoblastic leukemia (ALL), the prognostic impact has not been evaluated in allogeneic stem cell transplant (allo-SCT)… read more here.
Keywords: cytogenetic abnormalities; group; patients philadelphia; philadelphia chromosome ... See more keywords
Cytogenetic abnormalities in patients with newly diagnosed multiple myeloma as a secondary primary malignancy: a retrospective study
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DOI: 10.1080/16078454.2020.1757330
Abstract: ABSTRACT Objectives: Multiple myeloma (MM) often develops as a secondary primary malignancy (SPM). The retinoblastoma susceptibility gene (RB1) was the first tumour suppressor gene to be identified. We pooled and analyzed available data to compare… read more here.
Keywords: cytogenetic abnormalities; secondary primary; abnormalities patients; multiple myeloma ... See more keywords
AML with inv(16)/t(16;16) and high-risk cytogenetic abnormalities: atypical features and unfavorable outcome
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DOI: 10.1080/16078454.2022.2078027
Abstract: ABSTRACT Objectives Acute myeloid leukemia (AML) with inv(16)/t(16;16) is among the most frequent AML subtypes. It is recognized by the detection of the CBFB-MYH11 fusion which confers a favorable prognosis, irrespective of the presence of… read more here.
Keywords: cytogenetic abnormalities; risk; high risk; aml inv ... See more keywords
Clinical and Cytogenetic Characteristics of Children With Leukemia 20-Year Retrospective Study
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DOI: 10.1097/mph.0000000000002529
Abstract: Acute leukemias are the most common malignant diseases in childhood. The aims of this retrospective cohort study were to investigate the frequency of cytogenetic abnormalities in acute pediatric leukemia; the correlation between cytogenetic abnormalities and… read more here.
Keywords: year survival; year; leukemia; cytogenetic abnormalities ... See more keywords
Long‐term outcomes of aplastic anemia with cytogenetic abnormalities at diagnosis
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DOI: 10.1111/ejh.13913
Abstract: To elucidate the clinical characteristics of AA patients with cytogenetic abnormalities. read more here.
Keywords: long term; anemia cytogenetic; term outcomes; cytogenetic abnormalities ... See more keywords
IGH cytogenetic abnormalities can be detected in multiple myeloma by imaging flow cytometry
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DOI: 10.1136/jcp-2022-208230
Abstract: Aims Cytogenetic abnormalities involving the IGH gene are seen in up to 55% of patients with multiple myeloma. Current testing is performed manually by fluorescence in situ hybridisation (FISH) on purified plasma cells. We aimed… read more here.
Keywords: abnormalities detected; imaging flow; involving igh; cytogenetic abnormalities ... See more keywords
Complex cytogenetic abnormalities in chronic myeloid leukemia resulting in early progression to blast crisis: a case report
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DOI: 10.1186/s13256-020-02539-x
Abstract: Introduction BCR-ABL1, resulting from t(9;22), is the oncogenic driver of chronic myeloid leukemia and the therapeutic target of the disease. Molecular studies have been the gold standard modality for patient assessment since the advent of… read more here.
Keywords: cytogenetic abnormalities; myeloid leukemia; case; chronic myeloid ... See more keywords
Association of mutations with morphological dysplasia in de novo acute myeloid leukemia without 2016 WHO Classification-defined cytogenetic abnormalities
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DOI: 10.3324/haematol.2017.181842
Abstract: Despite improvements in our understanding of the molecular basis of acute myeloid leukemia (AML), the association between genetic mutations with morphological dysplasia remains unclear. In this study, we evaluated and scored dysplasia in bone marrow… read more here.
Keywords: cytogenetic abnormalities; myeloid leukemia; mutations morphological; dysplasia ... See more keywords
Relative impact of residual cytogenetic abnormalities and flow cytometric measurable residual disease on outcome after allogeneic hematopoietic cell transplantation in adult acute myeloid leukemia
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DOI: 10.3324/haematol.2022.281585
Abstract: Measurable residual disease (MRD) before hematopoietic cell transplantation (HCT) is an independent established prognostic factor in patients with acute myeloid leukemia (AML). Several methods exist to evaluate the presence of residual leukemia cells, but how… read more here.
Keywords: residual disease; residual cytogenetic; measurable residual; leukemia ... See more keywords