Molecular profiling of patients with cytogenetically normal acute myeloid leukemia and hyperleukocytosis
Sign Up to like & getrecommendations! Published in 2022 at "Cancer"
DOI: 10.1002/cncr.34495
Abstract: Acute myeloid leukemia (AML) with initial hyperleukocytosis is associated with high early mortality and a poor prognosis. The aims of this study were to delineate the underlying molecular landscape in the largest cytogenetic risk group,… read more here.
Keywords: cytogenetically normal; acute myeloid; myeloid leukemia; hyperleukocytosis ... See more keywords
Diagnosis and relapse: cytogenetically normal acute myelogenous leukemia without FLT3-ITD or MLL-PTD
Sign Up to like & getrecommendations! Published in 2017 at "Leukemia"
DOI: 10.1038/leu.2016.343
Abstract: Diagnosis and relapse: cytogenetically normal acute myelogenous leukemia without FLT3 -ITD or MLL -PTD read more here.
Keywords: normal acute; acute myelogenous; cytogenetically normal; relapse cytogenetically ... See more keywords
The clinical characteristics and prognosis of cytogenetically normal AML with single mutations of CEBPA.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of laboratory hematology"
DOI: 10.1111/ijlh.13612
Abstract: INTRODUCTION CEBPA mutation is a common mutation in normal karyotype AML. CEBPAdm AML has been recognized as a separate entity, but there is still controversy to the prognosis of CEBPAsm patients. METHODS A total of… read more here.
Keywords: normal aml; cytogenetically normal; cebpasm; cebpasm patients ... See more keywords
Molecular Mutations and Their Cooccurrences in Cytogenetically Normal Acute Myeloid Leukemia
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DOI: 10.1155/2017/6962379
Abstract: Adult acute myeloid leukemia (AML) clinically is a disparate disease that requires intensive treatments ranging from chemotherapy alone to allogeneic hematopoietic cell transplantation (allo-HCT). Historically, cytogenetic analysis has been a useful prognostic tool to classify… read more here.
Keywords: molecular mutations; myeloid leukemia; cytogenetically normal; mutations cooccurrences ... See more keywords
Prognostic and Biologic Relevance of Clinically Applicable Long Noncoding RNA Profiling in Older Patients with Cytogenetically Normal Acute Myeloid Leukemia
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DOI: 10.1158/1535-7163.mct-18-1125
Abstract: We have previously shown that expression levels of 48 long noncoding RNAs (lncRNA) can generate a prognostic lncRNA score that independently associates with outcome of older patients with cytogenetically normal acute myeloid leukemia (CN-AML). However,… read more here.
Keywords: cytogenetically normal; patients cytogenetically; rna; long noncoding ... See more keywords
Genetic heterogeneity of cytogenetically normal AML with mutations of CEBPA.
Sign Up to like & getrecommendations! Published in 2018 at "Blood advances"
DOI: 10.1182/bloodadvances.2018016840
Abstract: Biallelic mutations of the CCAAT/enhancer binding protein α (CEBPA) gene define a distinct genetic entity of acute myeloid leukemia (AML) with favorable prognosis. The presence of GATA2 and CSF3R mutations that are specifically associated with… read more here.
Keywords: genetic heterogeneity; normal aml; cytogenetically normal; group ... See more keywords
A 3-miRNA signature predicts prognosis of pediatric and adolescent cytogenetically normal acute myeloid leukemia
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DOI: 10.18632/oncotarget.17151
Abstract: Acute myeloid leukemia is a hematologic malignancy with significant molecular heterogeneity. MicroRNAs have important biological functions and play critical roles in pathogenesis and prognosis in a variety of cancers including acute myeloid leukemia. Some reports… read more here.
Keywords: myeloid leukemia; normal acute; cytogenetically normal; acute myeloid ... See more keywords
Long non-coding RNA expression profile in cytogenetically normal acute myeloid leukemia identifies a distinct signature and a new biomarker in NPM1-mutated patients
Sign Up to like & getrecommendations! Published in 2017 at "Haematologica"
DOI: 10.3324/haematol.2017.171645
Abstract: Long non-coding RNAs are defined as transcripts larger than 200 nucleotides but without protein-coding potential. There is growing evidence of the important role of long non-coding RNAs in cancer initiation, development and progression. In this… read more here.
Keywords: cytogenetically normal; long non; non coding; expression ... See more keywords
Overexpression of Prohibitin 2 Protein is Associated with Adverse Prognosis in Cytogenetically Normal Acute Myeloid Leukemia.
Sign Up to like & getrecommendations! Published in 2022 at "Annals of laboratory medicine"
DOI: 10.3343/alm.2022.42.5.585
Abstract: Cytogenetically normal acute myeloid leukemia (CN-AML) accounts for 40%-50% of all AML cases. Despite advances in understanding the molecular pathophysiology of CN-AML, its clinical outcome remains unsatisfactory and unpredictable. To investigate its clinical implication in… read more here.
Keywords: myeloid leukemia; acute myeloid; associated adverse; normal acute ... See more keywords