Clinically translatable cytokine delivery platform for eradication of intraperitoneal tumors
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abm1032
Abstract: Proinflammatory cytokines have been approved by the Food and Drug Administration for the treatment of metastatic melanoma and renal carcinoma. However, effective cytokine therapy requires high-dose infusions that can result in antidrug antibodies and/or systemic… read more here.
Keywords: delivery platform; cytokine delivery; translatable cytokine; clinically translatable ... See more keywords
Targeted Cytokine Delivery for Cancer Treatment: Engineering and Biological Effects
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics15020336
Abstract: Anti-tumor properties of several cytokines have already been investigated in multiple experiments and clinical trials. However, those studies evidenced substantial toxicities, even at low cytokine doses, and the lack of tumor specificity. These factors significantly… read more here.
Keywords: delivery cancer; targeted cytokine; cytokine delivery; tumor ... See more keywords