Individual genetic variability mainly of Proinflammatory cytokines, cytokine receptors, and toll‐like receptors dictates pathophysiology of COVID‐19 disease
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Virology"
DOI: 10.1002/jmv.27849
Abstract: Innate and acquired immunity responses are crucial for viral infection elimination. However, genetic variations in coding genes may exacerbate the inflammation or initiate devastating cytokine storms which poses severe respiratory conditions in coronavirus disease‐19 (COVID‐19).… read more here.
Keywords: toll like; cytokine receptors; cytokines cytokine; proinflammatory cytokines ... See more keywords
Pro- and anti-apoptotic fate decisions induced by di- and trimeric synthetic cytokine receptors
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DOI: 10.1016/j.isci.2021.102471
Abstract: Summary Synthetic strategies to activate cytokine receptors so far only address standard dimeric cytokine receptor assemblies. The 19 ligands of the tumor necrosis factor superfamily (TNFSF), however, form noncovalent trimers and receptor trimerization is considered… read more here.
Keywords: cytokine; cytokine receptors; fate decisions; synthetic cytokine ... See more keywords
Serially measured cytokines and cytokine receptors in relation to clinical outcome in patients with stable heart failure
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DOI: 10.1093/ehjci/ehaa946.0994
Abstract: Activation of the inflammatory response in heart failure (HF) may initially serve as a compensatory mechanism. However, on the longer term, this physiological phenomenon can become disadvantageous. Temporal patterns of inflammatory proteins other than CRP… read more here.
Keywords: cytokine receptors; measured cytokines; patients stable; heart failure ... See more keywords
JAK/STAT: Why choose a classical or an alternative pathway when you can have both?
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DOI: 10.1111/jcmm.17168
Abstract: A subset of cytokines triggers the JAK-STAT pathway to exert various functions such as the induction of inflammation and immune responses. The receptors for these cytokines are dimers/trimers of transmembrane proteins devoid of intracellular kinase… read more here.
Keywords: jak stat; stat; cytokine receptors; pathway ... See more keywords
Cytokine Receptors—Regulators of Antimycobacterial Immune Response
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DOI: 10.3390/ijms23031112
Abstract: Cytokine receptors are critical regulators of the antimycobacterial immune response, playing a key role in initiating and coordinating the recruitment and activation of immune cells during infection. They recognize and bind specific cytokines and are… read more here.
Keywords: antimycobacterial immune; regulators antimycobacterial; immune response; cytokine receptors ... See more keywords
The Role of Cytokines in the Metastasis of Solid Tumors to the Spine: Systematic Review
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DOI: 10.3390/ijms24043785
Abstract: Although many studies have investigated the role of cytokines in bone metastases, our knowledge of their function in spine metastasis is limited. Therefore, we performed a systematic review to map the available evidence on the… read more here.
Keywords: metastasis; motif chemokine; cytokine receptors; role ... See more keywords