Detailed overview of incidence and management of cytokine release syndrome observed with teclistamab in the MajesTEC-1 study of patients with relapsed/refractory multiple myeloma.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer"
DOI: 10.1002/cncr.34756
Abstract: Teclistamab, a B‐cell maturation antigen × CD3 bispecific antibody, demonstrated an overall response rate of 63.0% in 165 heavily pretreated patients with relapsed or refractory multiple myeloma in the phase 1/2 MajesTEC‐1 study. Cytokine release… read more here.
Keywords: relapsed refractory; refractory multiple; patients relapsed; multiple myeloma ... See more keywords
Cytokine release syndrome after allogeneic stem cell transplantation with posttransplant cyclophosphamide
Sign Up to like & getrecommendations! Published in 2020 at "Hematological Oncology"
DOI: 10.1002/hon.2772
Abstract: Cytokine release syndrome (CRS) is a systemic inflammatory response with aberrant immune activation and immune hyperstimulation, that leads to increased cytokine levels and inflammation. CRS has been described after antibody and cellular‐based therapies. The use… read more here.
Keywords: cytokine release; crs; hsct; release syndrome ... See more keywords
Measuring Histamine and Cytokine Release from Basophils and Mast Cells.
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DOI: 10.1007/978-1-0716-0696-4_21
Abstract: Basophils and mast cells are known for their capability to release both preformed and newly synthesized inflammatory mediators. In this chapter, we describe how to stimulate and detect histamine released from basophils in whole blood,… read more here.
Keywords: mast cells; cytokine release; measuring histamine; basophils mast ... See more keywords
Unexpected and striking effect of heparin-free dialysis on cytokine release
Sign Up to like & getrecommendations! Published in 2017 at "International Urology and Nephrology"
DOI: 10.1007/s11255-017-1589-8
Abstract: Heparin (both unfractionated and low molecular weight) is not only a potent anticoagulant but also has many pleiotropic effects, some of which are mediated by cytokine release. We compared the effect of hemodialysis (HD) with… read more here.
Keywords: cytokine release; striking effect; effect heparin; effect ... See more keywords
Biomarkers of Cardiac Stress and Cytokine Release Syndrome in COVID-19: A Review
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DOI: 10.1007/s11897-021-00505-2
Abstract: Purpose of Review The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) resulted in the coronavirus 2019 (COVID-19) global pandemic. While primarily a respiratory virus, SARS-CoV-2 can cause myocardial injury. The pattern of injury, referred to… read more here.
Keywords: cytokine release; covid; review; injury ... See more keywords
Transdermal delivery of oleanolic acid attenuates pro-inflammatory cytokine release and ameliorates anaemia in P. berghei malaria.
Sign Up to like & getrecommendations! Published in 2017 at "Acta tropica"
DOI: 10.1016/j.actatropica.2017.03.005
Abstract: Malaria remains a major health problem in many tropical areas. Severe malaria infection is associated with secondary complications including anaemia leading to a need for the search of affordable antimalarial agents that can clear the… read more here.
Keywords: cytokine; malaria; cytokine release; anaemia ... See more keywords
A novel platform for in vivo detection of cytokine release within discrete brain regions
Sign Up to like & getrecommendations! Published in 2018 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2018.04.011
Abstract: Mounting evidence indicates that cytokines secreted by innate immune cells in the brain play a central role in regulating neural circuits that subserve mood, cognition, and sickness responses. A major impediment to the study of… read more here.
Keywords: cytokine release; brain; detection; vivo detection ... See more keywords
An inflammatory stimulus sensitizes TRPA1 channel to increase cytokine release in human lung fibroblasts.
Sign Up to like & getrecommendations! Published in 2020 at "Cytokine"
DOI: 10.1016/j.cyto.2020.155027
Abstract: External stimuli such as cigarette smoke and house dust mite are often involved in the development and exacerbation of asthma. These risk factors could activate or sensitize transient receptor potential channel ankyrin 1 (TRPA1), which… read more here.
Keywords: lung fibroblasts; cytokine release; human lung; trpa1 channel ... See more keywords
COVID-19: A New Virus, but a Familiar Receptor and Cytokine Release Syndrome
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DOI: 10.1016/j.immuni.2020.04.003
Abstract: Summary Zhou et al. (Nature) and Hoffmann et al. (Cell) identify ACE2 as a SARS-CoV-2 receptor, and the latter show its entry mechanism depends on cellular serine protease TMPRSS2. These results may explain proinflammatory cytokine release via the… read more here.
Keywords: receptor; cytokine release; covid new; new virus ... See more keywords
Polarized cytokine release from airway epithelium differentially influences macrophage phenotype.
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DOI: 10.1016/j.molimm.2021.01.029
Abstract: Epithelial cells and macrophages represent two major cell populations in the lung. They reside in physical proximity and are influenced by inhaled substances, microbial- and host-derived factors, as well as by crosstalk between each other.… read more here.
Keywords: macrophage phenotype; cytokine release; apical basolateral; expression ... See more keywords
Ultraviolet-A light reduces cellular cytokine release from human endotracheal cells infected with Coronavirus
Sign Up to like & getrecommendations! Published in 2021 at "Photodiagnosis and Photodynamic Therapy"
DOI: 10.1016/j.pdpdt.2021.102457
Abstract: Background An important clinical feature of coronavirus disease 2019 (COVID-19) is hypercytokinemia (cytokine storm). We previously showed that narrow band ultraviolet-A (NB-UVA) treatment salvages coronavirus (CoV)-229E-infected human tracheal cells, and that daily endotracheal NB-UVA therapy… read more here.
Keywords: uva; cytokine release; 229e infected; cov 229e ... See more keywords