SOCS3 is a suppressor of γc cytokine signaling and constrains generation of murine Foxp3+ regulatory T cells
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Immunology"
DOI: 10.1002/eji.201948307
Abstract: SOCS3 is a cytosolic inhibitor of cytokine signaling that suppresses the activation of cytokine receptor‐associated JAK kinases. Mechanistically, SOCS3 is recruited to a site in the cytokine receptors known as the SOCS3‐interaction motif, and then… read more here.
Keywords: cytokine; socs3; foxp3 regulatory; cytokine signaling ... See more keywords
Hepatitis B virus X protein impairs α‐interferon signaling via up‐regulation of suppressor of cytokine signaling 3 and protein phosphatase 2A
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Medical Virology"
DOI: 10.1002/jmv.24643
Abstract: Hepatitis B Virus (HBV) causes liver cirrhosis and hepatocellular carcinoma. Standard therapy includes treatment with interferon (IFN); however, its efficacy is limited. HBV has been reported to impair IFN signaling; however, the mechanism is unclear.… read more here.
Keywords: protein; cytokine signaling; pp2a; hepatitis virus ... See more keywords
Cytokine signaling pathway in cystic fibrosis: expression of SOCS and STATs genes in different clinical phenotypes of the disease.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular and cellular biochemistry"
DOI: 10.1007/s11010-021-04051-2
Abstract: This was an observational cross-sectional study which was done to assess the expression profile of STATs and SOCS genes in cystic fibrosis. The mRNA was isolated from peripheral blood mononuclear cells of CF patients in… read more here.
Keywords: cystic fibrosis; cytokine signaling; socs; signaling pathway ... See more keywords
Deleting Suppressor of Cytokine Signaling-3 in chondrocytes reduces bone growth by disrupting mitogen-activated protein kinase signaling.
Sign Up to like & getrecommendations! Published in 2019 at "Osteoarthritis and cartilage"
DOI: 10.1016/j.joca.2019.05.018
Abstract: OBJECTIVE To investigate the impact of deleting Suppressor of Cytokine Signaling (SOCS)-3 (SOCS3) in chondrocytes during murine skeletal development. METHOD Mice with a conditional Socs3 allele (Socs3fl/fl) were crossed with a transgenic mouse expressing Cre… read more here.
Keywords: socs3; deleting suppressor; cytokine signaling; mice ... See more keywords
Suppressor of cytokine signaling genes in renal transplant receivers: Association with transplant fate.
Sign Up to like & getrecommendations! Published in 2019 at "Transplant immunology"
DOI: 10.1016/j.trim.2019.101228
Abstract: Suppressor of cytokine signaling (SOCS) proteins have acknowledged roles in regulation of immune responses. Moreover, their role in the evolution of allograft rejection is being elucidated. In the current investigation, we measured transcript levels of… read more here.
Keywords: cytokine signaling; group; transplant; non rejected ... See more keywords
Clinico-biological significance of suppressor of cytokine signaling 1 expression in acute myeloid leukemia
Sign Up to like & getrecommendations! Published in 2017 at "Blood Cancer Journal"
DOI: 10.1038/bcj.2017.67
Abstract: Suppressor of cytokine signaling 1 (SOCS1) protein, which encodes a member of signal transducers and activators of transcription-induced inhibitors, takes part in a negative regulation of cytokine signaling. The mechanism of SOCS1 in tumor carcinogenesis… read more here.
Keywords: cytokine signaling; expression; myeloid; leukemia ... See more keywords
Systematic investigation of cytokine signaling activity at the tissue and single-cell levels.
Sign Up to like & getrecommendations! Published in 2021 at "Nature methods"
DOI: 10.1038/s41592-021-01274-5
Abstract: Cytokines are critical for intercellular communication in human health and disease, but the investigation of cytokine signaling activity has remained challenging due to the short half-lives of cytokines and the complexity/redundancy of cytokine functions. To… read more here.
Keywords: single cell; cytokine; cytokine signaling; signaling activity ... See more keywords
Targeting cytokine signaling checkpoint CIS activates NK cells to protect from tumor initiation and metastasis
Sign Up to like & getrecommendations! Published in 2017 at "OncoImmunology"
DOI: 10.1080/2162402x.2016.1267892
Abstract: ABSTRACT The cytokine-induced SH2-containing protein CIS belongs to the suppressor of cytokine signaling (SOCS) protein family. Here, we show the critical role of CIS in suppressing natural killer (NK) cell control of tumor initiation and… read more here.
Keywords: cis; cytokine signaling; metastasis; tumor initiation ... See more keywords
Characterization of the roles of suppressor of cytokine signaling-3 in esophageal carcinoma.
Sign Up to like & getrecommendations! Published in 2023 at "Human gene therapy"
DOI: 10.1089/hum.2022.185
Abstract: This study was aimed to analyze the diagnostic, therapeutic and prognostic value of the suppressor of cytokine signaling 3 (SOCS3) in pancancer, especially in esophageal carcinoma (ESCA), and investigate the role of SOCS3 in the… read more here.
Keywords: socs3; cytokine signaling; expression; esca ... See more keywords
SOCS: negative regulators of cytokine signaling for immune tolerance.
Sign Up to like & getrecommendations! Published in 2021 at "International immunology"
DOI: 10.1093/intimm/dxab055
Abstract: Cytokines are important intercellular communication tools for immunity. Many cytokines promote gene transcription and proliferation through the JAK/STAT (Janus kinase / signal transducers and activators of transcription) and the Ras/ERK (GDP/GTP-binding rat sarcoma protein /… read more here.
Keywords: negative regulators; cytokine signaling; immune tolerance; socs negative ... See more keywords
Is PTSD an Evolutionary Survival Adaptation Initiated by Unrestrained Cytokine Signaling and Maintained by Epigenetic Change?
Sign Up to like & getrecommendations! Published in 2022 at "Military medicine"
DOI: 10.1093/milmed/usac095
Abstract: INTRODUCTION Treatment outcomes for PTSD with current psychological therapies are poor, with very few patients achieving sustained symptom remission. A number of authors have identified physiological and immune disturbances in Post Traumatic Stress Disorder (PTSD)… read more here.
Keywords: cytokine; adaptation; cytokine signaling; ptsd ... See more keywords