The Suppressor of Cytokine Signalling family of proteins and their potential impact on COVID-19 disease progression.
Sign Up to like & getrecommendations! Published in 2021 at "Reviews in medical virology"
DOI: 10.1002/rmv.2300
Abstract: The family of Suppressor of Cytokine Signalling (SOCS) proteins plays pivotal roles in cytokine and immune regulation. Despite their key roles, little attention has been given to the SOCS family as compared to other feedback… read more here.
Keywords: cytokine signalling; family; socs protein; virus ... See more keywords
Rheumatoid arthritis: Modelling cytokine signalling networks
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DOI: 10.1038/nrrheum.2016.194
Abstract: Although an imbalance between proinflammatory and anti-inflammatory cytokines has been implicated in rheumatoid arthritis (RA), the identification of specific cytokines regulating RA pathophysiology is still challenging. Modelling cytokine signalling networks and evaluating associated pathway activities… read more here.
Keywords: cytokine signalling; modelling cytokine; arthritis modelling; rheumatoid arthritis ... See more keywords
Dysregulation of immune cell and cytokine signalling correlates with clinical outcomes in myelodysplastic syndrome (MDS)
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DOI: 10.1111/ejh.13742
Abstract: Myelodysplastic syndromes (MDS) are characterised by ineffective haematopoiesis. Although hypomethylating agents (HMA) have improved survival in higher‐risk MDS, most patients eventually succumb to progressive disease. Utilising samples collected prospectively from three MDS clinical trials, we… read more here.
Keywords: cytokine signalling; cell cytokine; mds; immune cell ... See more keywords
Suppressor of Cytokine Signalling 5 (SOCS5) Modulates Inflammatory Responses during Alphavirus Infection
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DOI: 10.3390/v14112476
Abstract: CNS viral infections are one of the major causes of morbidity and mortality worldwide and a significant global public health concern. Uncontrolled inflammation and immune responses in the brain, despite their protective roles, can also… read more here.
Keywords: socs5 modulates; infection; cytokine signalling; brain ... See more keywords