Diminished cytolytic activity of γδ T cells with reduced DNAM-1 expression in neuroblastoma patients.
Sign Up to like & getrecommendations! Published in 2019 at "Clinical immunology"
DOI: 10.1016/j.clim.2019.04.006
Abstract: Neuroblastoma is one of the children's malignant tumors with poor prognosis, as well as high recurrence and metastasis rates after surgical removal and chemotherapy. γδ T-cell based immunotherapy receives increasing attention thanks to the strong… read more here.
Keywords: cell; activity; dnam expression; cytolytic activity ... See more keywords
Impaired natural killer cell counts and cytolytic activity in patients with severe COVID-19
Sign Up to like & getrecommendations! Published in 2020 at "Blood Advances"
DOI: 10.1182/bloodadvances.2020002650
Abstract: Abstract The global pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)–driven coronavirus disease 2019 (COVID-19) has caused unprecedented human death and has seriously threatened the global economy. Early data suggest a surge in proinflammatory… read more here.
Keywords: patients severe; cell; activity; counts cytolytic ... See more keywords
Identification of Novel Molecular Therapeutic Targets and Their Potential Prognostic Biomarkers Based on Cytolytic Activity in Skin Cutaneous Melanoma
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.844666
Abstract: Skin cutaneous melanoma (SKCM) attracts attention worldwide for its extremely high malignancy. A novel term cytolytic activity (CYT) has been introduced as a potential immunotherapy biomarker associated with counter-regulatory immune responses and enhanced prognosis in… read more here.
Keywords: database; skin cutaneous; cutaneous melanoma; cytolytic activity ... See more keywords
Immunomodulatory Factor TIM3 of Cytolytic Active Genes Affected the Survival and Prognosis of Lung Adenocarcinoma Patients by Multi-Omics Analysis
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10092248
Abstract: [Objective] Using multi-omics research methods to explore cytolytic activity-related genes through the immunoregulatory factors HAVCR2 (TIM3) affecting the survival and prognosis of lung adenocarcinoma. [Methods] We combined Cox single factor regression and lasso regression feature… read more here.
Keywords: multi omics; prognosis; lung adenocarcinoma; cytolytic activity ... See more keywords
Immune Cytolytic Activity for Comprehensive Understanding of Immune Landscape in Hepatocellular Carcinoma
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DOI: 10.3390/cancers12051221
Abstract: Cytolytic activity score (CYT), defined by granzyme A and perforin expression, is a useful marker for underlying immunity. We hypothesized that CYT-high hepatocellular carcinomas (HCCs) have stronger immunogenicity and favorable tumor microenvironments, which would result… read more here.
Keywords: cyt high; cytolytic activity; high hccs; hccs ... See more keywords