Molecular dynamics at immune synapse lipid rafts influence the cytolytic behavior of CAR T cells
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DOI: 10.1126/sciadv.adq8114
Abstract: Chimeric antigen receptor T cells (CART) targeting CD19 through CD28.ζ signaling induce rapid lysis of leukemic blasts, contrasting with persistent tumor control exhibited by 4-1BB.ζ-CART. We reasoned that molecular dynamics at the CART immune synapse… read more here.
Keywords: caris; cytolytic behavior; lipid rafts; immune synapse ... See more keywords