Nanoparticle-Mediated Cytoplasmic Delivery of Messenger RNA Vaccines: Challenges and Future Perspectives
Sign Up to like & getrecommendations! Published in 2021 at "Pharmaceutical Research"
DOI: 10.1007/s11095-021-03015-x
Abstract: The COVID-19 pandemic has left scientists and clinicians no choice but a race to find solutions to save lives while controlling the rapid spreading. Messenger RNA (mRNA)-based vaccines have become the front-runners because of their… read more here.
Keywords: vaccines challenges; delivery; future perspectives; messenger rna ... See more keywords
Strategy for Cytoplasmic Delivery Using Inorganic Particles.
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DOI: 10.1007/s11095-022-03178-1
Abstract: Endosome escape is a key process for intracellular uptake of intact biomolecules and therapeutics, such as nucleic acids. Lysosome escape is a more common pathway during endocytosis, while some biomolecular, organic and inorganic materials are… read more here.
Keywords: cytoplasmic delivery; endosome escape; delivery; strategy cytoplasmic ... See more keywords
Engineering of Extracellular Vesicles for Small Molecule-Regulated Cargo Loading and Cytoplasmic Delivery of Bioactive Proteins.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.2c00192
Abstract: Cytoplasmic delivery of functional proteins into target cells remains challenging for many biological agents to exert their therapeutic effects. Extracellular vesicles (EVs) are expected to be a promising platform for protein delivery; however, efficient loading… read more here.
Keywords: cargo; extracellular vesicles; cytoplasmic delivery; bioactive proteins ... See more keywords