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Published in 2021 at "Cell"
DOI: 10.1016/j.cell.2021.09.034
Abstract: Endogenous cytoplasmic DNA (cytoDNA) species are emerging as key mediators of inflammation in diverse physiological and pathological contexts. Although the role of endogenous cytoDNA in innate immune activation is well established, the cytoDNA species themselves…
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Keywords:
dna;
cytoplasmic dna;
dna sources;
sensing role ... See more keywords
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Published in 2020 at "Journal of autoimmunity"
DOI: 10.1016/j.jaut.2019.102381
Abstract: Primary Sjögren's syndrome (SS) is characterized by chronic periductal inflammatory infiltrates in the salivary glands. Several previous studies have indicated that the ductal epithelia of SS patients play a pro-inflammatory role and manifest an intrinsically…
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Keywords:
sgec lines;
aim2;
dna;
cytoplasmic dna ... See more keywords
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Published in 2017 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkx001
Abstract: Abstract Foreign and self-cytoplasmic DNA are recognized by numerous DNA sensor molecules leading to the production of type I interferons. Such DNA agonists should be degraded otherwise cells would be chronically stressed. Most human APOBEC3…
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Keywords:
dna damage;
apobec3a;
dna;
self cytoplasmic ... See more keywords
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Published in 2019 at "Genetics"
DOI: 10.1534/genetics.119.302422
Abstract: Caenorhabditis elegans possesses a rudimentary innate immune response that serves as a model for various aspects of the human innate immune response. To date, a nematode response to pathogenic cytoplasmic DNA has not been identified...…
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Keywords:
inflammation like;
cytoplasmic dna;
response;
caenorhabditis elegans ... See more keywords
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Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1117760
Abstract: Cytoplasmic DNA is emerging as a pivotal contributor to the pathogenesis of inflammatory diseases and cancer, such as COVID-19 and lung carcinoma. However, the complexity of various cytoplasmic DNA-related pathways and their crosstalk remains challenging…
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Keywords:
lung;
cancer;
cytoplasmic dna;
inflammatory diseases ... See more keywords