Cytoplasmic DNA: sources, sensing, and role in aging and disease
Sign Up to like & getrecommendations! Published in 2021 at "Cell"
DOI: 10.1016/j.cell.2021.09.034
Abstract: Endogenous cytoplasmic DNA (cytoDNA) species are emerging as key mediators of inflammation in diverse physiological and pathological contexts. Although the role of endogenous cytoDNA in innate immune activation is well established, the cytoDNA species themselves… read more here.
Keywords: dna; cytoplasmic dna; dna sources; sensing role ... See more keywords
Cell-autonomous epithelial activation of AIM2 (absent in melanoma-2) inflammasome by cytoplasmic DNA accumulations in primary Sjögren's syndrome.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of autoimmunity"
DOI: 10.1016/j.jaut.2019.102381
Abstract: Primary Sjögren's syndrome (SS) is characterized by chronic periductal inflammatory infiltrates in the salivary glands. Several previous studies have indicated that the ductal epithelia of SS patients play a pro-inflammatory role and manifest an intrinsically… read more here.
Keywords: sgec lines; aim2; dna; cytoplasmic dna ... See more keywords
Self-cytoplasmic DNA upregulates the mutator enzyme APOBEC3A leading to chromosomal DNA damage
Sign Up to like & getrecommendations! Published in 2017 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkx001
Abstract: Abstract Foreign and self-cytoplasmic DNA are recognized by numerous DNA sensor molecules leading to the production of type I interferons. Such DNA agonists should be degraded otherwise cells would be chronically stressed. Most human APOBEC3… read more here.
Keywords: dna damage; apobec3a; dna; self cytoplasmic ... See more keywords
Restoration of Proteostasis in the Endoplasmic Reticulum Reverses an Inflammation-Like Response to Cytoplasmic DNA in Caenorhabditis elegans
Sign Up to like & getrecommendations! Published in 2019 at "Genetics"
DOI: 10.1534/genetics.119.302422
Abstract: Caenorhabditis elegans possesses a rudimentary innate immune response that serves as a model for various aspects of the human innate immune response. To date, a nematode response to pathogenic cytoplasmic DNA has not been identified...… read more here.
Keywords: inflammation like; cytoplasmic dna; response; caenorhabditis elegans ... See more keywords
Cytoplasmic DNAs: Sources, sensing, and roles in the development of lung inflammatory diseases and cancer
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1117760
Abstract: Cytoplasmic DNA is emerging as a pivotal contributor to the pathogenesis of inflammatory diseases and cancer, such as COVID-19 and lung carcinoma. However, the complexity of various cytoplasmic DNA-related pathways and their crosstalk remains challenging… read more here.
Keywords: lung; cancer; cytoplasmic dna; inflammatory diseases ... See more keywords