Co‐expression of alpha‐1 antitrypsin with cytoplasmic domain of v‐SNARE in Pichia pastoris: Preserving biological activity of alpha‐1 antitrypsin
Sign Up to like & getrecommendations! Published in 2018 at "Biotechnology and Applied Biochemistry"
DOI: 10.1002/bab.1578
Abstract: Alpha‐1‐antitrypsin (A1AT) is a major serum protein in human with protease inhibitory activity. Because of its extensive application in medicine, recombinant DNA technology has been considered for its production. The current study examines coexpression of… read more here.
Keywords: biological activity; domain snare; cytoplasmic domain; alpha antitrypsin ... See more keywords
The β8 integrin EGF domains support a constitutive extended conformation, and the cytoplasmic domain impairs outside‐in signaling
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30871
Abstract: Integrins are transmembrane proteins that transmit bi‐directional signals across the cell membrane through global structural rearrangement among three different conformational states: bent, extended‐ closed, and extended‐open conformations. However, the β8 integrin is distinctive and may… read more here.
Keywords: conformation; ligand binding; outside signaling; extended conformation ... See more keywords
In Silico Identification of Potential Phosphorylation in the Cytoplasmic Domain of Epithelial Cell Adhesion Molecule
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DOI: 10.1021/acsomega.0c02113
Abstract: The epithelial cell adhesion molecule (EpCAM) is a transmembrane cell adhesion glycoprotein, which primarily contributes to stemness, proliferation, and metastasis properties of tumor cells. Regulated intramembrane proteolysis by ADAM proteases and γ-secretase cleaves EpCAM into… read more here.
Keywords: phosphorylation; cytoplasmic domain; cell adhesion;
PD-L1 degradation is regulated by electrostatic membrane association of its cytoplasmic domain
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DOI: 10.1038/s41467-021-25416-7
Abstract: The cytoplasmic domain of PD-L1 (PD-L1-CD) regulates PD-L1 degradation and stability through various mechanism, making it an attractive target for blocking PD-L1-related cancer signaling. Here, by using NMR and biochemical techniques we find that the… read more here.
Keywords: association; membrane association; degradation; cytoplasmic domain ... See more keywords
The First 3D Model of the Full-Length KIT Cytoplasmic Domain Reveals a New Look for an Old Receptor
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DOI: 10.1038/s41598-020-62460-7
Abstract: Receptor tyrosine kinases (RTKs) are key regulators of normal cellular processes and have a critical role in the development and progression of many diseases. RTK ligand-induced stimulation leads to activation of the cytoplasmic kinase domain… read more here.
Keywords: full length; model; kit; cytoplasmic domain ... See more keywords
Specific residues in the cytoplasmic domain modulate photocurrent kinetics of channelrhodopsin from Klebsormidium nitens
Sign Up to like & getrecommendations! Published in 2021 at "Communications Biology"
DOI: 10.1038/s42003-021-01755-5
Abstract: Channelrhodopsins (ChRs) are light-gated ion channels extensively applied as optogenetics tools for manipulating neuronal activity. All currently known ChRs comprise a large cytoplasmic domain, whose function is elusive. Here, we report the cation channel properties… read more here.
Keywords: klebsormidium nitens; photocurrent kinetics; domain; cytoplasmic domain ... See more keywords
TMEM106B, a risk factor for FTLD and aging, has an intrinsically disordered cytoplasmic domain
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DOI: 10.1371/journal.pone.0205856
Abstract: TMEM106B was initially identified as a risk factor for FTLD, but recent studies highlighted its general role in neurodegenerative diseases. Very recently TMEM106B has also been characterized to regulate aging phenotypes. TMEM106B is a 274-residue… read more here.
Keywords: factor ftld; tmem106b; cytoplasmic domain; risk factor ... See more keywords
A cellular trafficking signal in the SIV envelope protein cytoplasmic domain is strongly selected for in pathogenic infection
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DOI: 10.1371/journal.ppat.1010507
Abstract: The HIV/SIV envelope glycoprotein (Env) cytoplasmic domain contains a highly conserved Tyr-based trafficking signal that mediates both clathrin-dependent endocytosis and polarized sorting. Despite extensive analysis, the role of these functions in viral infection and pathogenesis… read more here.
Keywords: infection; siv envelope; trafficking signal; cytoplasmic domain ... See more keywords
Isoforms of Human MARCH1 Differ in Ability to Restrict Influenza A Viruses Due to Differences in Their N Terminal Cytoplasmic Domain
Sign Up to like & getrecommendations! Published in 2022 at "Viruses"
DOI: 10.3390/v14112549
Abstract: MARCH1 and MARCH8 are closely related E3 ubiquitin ligases that ubiquitinate an overlapping spectrum of host proteins and restrict replication of certain viruses. While the antiviral activity of MARCH8 has been intensively studied, less is… read more here.
Keywords: ability; terminal cytoplasmic; march1; differences terminal ... See more keywords