Dynarrestin, a Novel Inhibitor of Cytoplasmic Dynein.
Sign Up to like & getrecommendations! Published in 2018 at "Cell chemical biology"
DOI: 10.1016/j.chembiol.2017.12.014
Abstract: Aberrant hedgehog (Hh) signaling contributes to the pathogenesis of multiple cancers. Available inhibitors target Smoothened (Smo), which can acquire mutations causing drug resistance. Thus, compounds that inhibit Hh signaling downstream of Smo are urgently needed.… read more here.
Keywords: inhibitor cytoplasmic; dynein; novel inhibitor; cytoplasmic dynein ... See more keywords
Cytoplasmic Dynein Functions in Planar Polarization of Basal Bodies within Ciliated Cells
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DOI: 10.1016/j.isci.2020.101213
Abstract: Summary Despite common consensus about the importance of planar cell polarity (PCP) proteins in tissue orientation, little is known about the mechanisms used by PCP proteins to promote planar polarization of cytoskeletons within individual cells.… read more here.
Keywords: basal bodies; cell; planar polarization; cytoplasmic dynein ... See more keywords
Continuum Mechanical Parameterisation of Cytoplasmic Dynein from Atomistic Simulation.
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DOI: 10.1016/j.ymeth.2020.01.021
Abstract: Cytoplasmic dynein is responsible for intra-cellular transport in eukaryotic cells. Using Fluctuating Finite Element Analysis (FFEA), a novel algorithm that represents proteins as continuum viscoelastic solids subject to thermal noise, we are building computational tools… read more here.
Keywords: dynein; dynein atomistic; mechanical parameterisation; continuum mechanical ... See more keywords
Dynamic catch-bonding generates the large stall forces of cytoplasmic dynein.
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DOI: 10.1088/1478-3975/ab907d
Abstract: Cytoplasmic dynein is an important molecular motor involved in the transport of vesicular and macromolecular cargo along microtubules in cells, often in conjunction with kinesin motors. Dynein is larger and more complex than kinesin and… read more here.
Keywords: large stall; catch bonding; stall forces; cytoplasmic dynein ... See more keywords
A mathematical understanding of how cytoplasmic dynein walks on microtubules
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DOI: 10.1098/rsos.171568
Abstract: Cytoplasmic dynein 1 (hereafter referred to simply as dynein) is a dimeric motor protein that walks and transports intracellular cargos towards the minus end of microtubules. In this article, we formulate, based on physical principles,… read more here.
Keywords: walks microtubules; dynein; model; dynein walks ... See more keywords
Cytoplasmic dynein-2 at a glance
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DOI: 10.1242/jcs.240614
Abstract: ABSTRACT Cytoplasmic dynein-2 is a motor protein complex that drives the movement of cargoes along microtubules within cilia, facilitating the assembly of these organelles on the surface of nearly all mammalian cells. Dynein-2 is crucial… read more here.
Keywords: cell; dynein; biology; cytoplasmic dynein ... See more keywords