Formylation of Eukaryotic Cytoplasmic Proteins: Linking Stress to Degradation.
Sign Up to like & getrecommendations! Published in 2019 at "Trends in biochemical sciences"
DOI: 10.1016/j.tibs.2018.12.008
Abstract: Unlike prokaryotes, N-terminal formylation has been confined to a handful of mitochondrial proteins in eukaryotes. A recent study unveils a new role for eukaryotic cytoplasmic N-terminal formylation linking diverse cellular stresses to N-terminal-dependent protein degradation.… read more here.
Keywords: formylation; degradation; eukaryotic cytoplasmic; formylation eukaryotic ... See more keywords
Catalytic Promiscuity of O-GlcNAc Transferase Enables Unexpected Metabolic Engineering of Cytoplasmic Proteins with 2-Azido-2-deoxy-glucose.
Sign Up to like & getrecommendations! Published in 2017 at "ACS chemical biology"
DOI: 10.1021/acschembio.6b00876
Abstract: O-GlcNAc transferase (OGT) catalyzes the installation of N-acetylglucosamine (GlcNAc) O-linked to nucleocytoplasmic proteins (O-GlcNAc) within multicellular eukaryotes. OGT shows surprising tolerance for structural changes in the sugar component of its nucleotide sugar donor substrate, uridine… read more here.
Keywords: glcnac; azido deoxy; glcnac transferase; deoxy glucose ... See more keywords
SPINDLY O-fucosylates nuclear and cytoplasmic proteins involved in diverse cellular processes in plants.
Sign Up to like & getrecommendations! Published in 2023 at "Plant physiology"
DOI: 10.1093/plphys/kiad011
Abstract: SPINDLY (SPY) is a novel nucleocytoplasmic protein O-fucosyltransferase that regulates target protein activity or stability via O-fucosylation of specific Ser/Thr residues. Previous genetic studies indicate that AtSPY regulates plant development during vegetative and reproductive growth… read more here.
Keywords: diverse cellular; spindly fucosylates; fucosylates nuclear; cytoplasmic proteins ... See more keywords
Impact of c-di-GMP on the Extracellular Proteome of Rhizobium etli
Sign Up to like & getrecommendations! Published in 2022 at "Biology"
DOI: 10.3390/biology12010044
Abstract: Simple Summary The second messenger cyclic diguanylate (c-di-GMP, cdG) is a bacterial lifestyle-switch molecule, well known for its role in biofilm formation. Extracellular biofilm matrix components include diverse biopolymers such as polysaccharides, nucleic acids, proteins… read more here.
Keywords: cdg; proteome rhizobium; rhizobium etli; gap ... See more keywords