Translation of cytoplasmic UBA1 contributes to VEXAS syndrome pathogenesis.
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DOI: 10.1182/blood.2022016985
Abstract: Somatic mutations in UBA1 cause VEXAS (Vacuoles, E1 ubiquitin activating enzyme, X-linked, Autoinflammatory Somatic) syndrome, an adult-onset inflammatory disease with an overlap of hematologic manifestations. VEXAS syndrome is characterized by a high mortality rate and… read more here.
Keywords: cytoplasmic uba1; uba1 contributes; pathogenesis; vexas syndrome ... See more keywords