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Published in 2018 at "Toxicology and Applied Pharmacology"
DOI: 10.1016/j.taap.2018.08.001
Abstract: &NA; PIKfyve phosphoinositide kinase produces PtdIns(3,5)P2 and PtdIns5P and governs a myriad of cellular processes including cytoskeleton rearrangements and cell proliferation. The latter entails rigorous investigation since the cytotoxicity of PIKfyve inhibition is a potential…
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Keywords:
excessive cytoplasmic;
pikfyve;
cytoplasmic vacuolation;
inhibitor ... See more keywords
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Published in 2019 at "Toxicologic Pathology"
DOI: 10.1177/0192623319836678
Abstract: Drug-induced unique cytoplasmic vacuolation was found in the subchronic oral toxicity study of 4-dimethylamino-1-{3-(1-methyl-1H-imidazole-2-yl)propanoyl}piperidine (DMIP), a potential therapeutic agent for neuropathic pain, in beagle dogs. In the first study, DMIP was administered at a dose…
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Keywords:
vacuolation tapetal;
cytoplasmic vacuolation;
beagle dogs;
vacuolation ... See more keywords
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Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23137257
Abstract: Methuosis is a type of programmed cell death in which the cytoplasm is occupied by fluid-filled vacuoles that originate from macropinosomes (cytoplasmic vacuolation). A few molecules have been reported to behave as methuosis inducers in…
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Keywords:
cell death;
cytoplasmic vacuolation;
cell;
jaspine ... See more keywords