Articles with "cytoplasmic vacuolation" as a keyword



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PIKfyve inhibitor cytotoxicity requires AKT suppression and excessive cytoplasmic vacuolation

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Published in 2018 at "Toxicology and Applied Pharmacology"

DOI: 10.1016/j.taap.2018.08.001

Abstract: &NA; PIKfyve phosphoinositide kinase produces PtdIns(3,5)P2 and PtdIns5P and governs a myriad of cellular processes including cytoskeleton rearrangements and cell proliferation. The latter entails rigorous investigation since the cytotoxicity of PIKfyve inhibition is a potential… read more here.

Keywords: excessive cytoplasmic; pikfyve; cytoplasmic vacuolation; inhibitor ... See more keywords
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Cytoplasmic Vacuolation and Tapetal Changes Induced by a Novel Analgesic Agent in Beagle Dogs

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Published in 2019 at "Toxicologic Pathology"

DOI: 10.1177/0192623319836678

Abstract: Drug-induced unique cytoplasmic vacuolation was found in the subchronic oral toxicity study of 4-dimethylamino-1-{3-(1-methyl-1H-imidazole-2-yl)propanoyl}piperidine (DMIP), a potential therapeutic agent for neuropathic pain, in beagle dogs. In the first study, DMIP was administered at a dose… read more here.

Keywords: vacuolation tapetal; cytoplasmic vacuolation; beagle dogs; vacuolation ... See more keywords
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Methuosis Contributes to Jaspine-B-Induced Cell Death

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Published in 2022 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms23137257

Abstract: Methuosis is a type of programmed cell death in which the cytoplasm is occupied by fluid-filled vacuoles that originate from macropinosomes (cytoplasmic vacuolation). A few molecules have been reported to behave as methuosis inducers in… read more here.

Keywords: cell death; cytoplasmic vacuolation; cell; jaspine ... See more keywords