Key Role of TFEB Nucleus Translocation for Silver Nanoparticle-Induced Cytoprotective Autophagy.
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DOI: 10.1002/smll.201703711
Abstract: Transcription factor EB (TFEB) is a master regulator of autophagy and lysosomal biogenesis. Here, silver nanoparticles (Ag NPs)-induced cytoprotective autophagy required TFEB is shown. Ag NPs-induced nucleus translocation of TFEB through a well-established mechanism involving… read more here.
Keywords: nucleus translocation; cytoprotective autophagy; induced cytoprotective; autophagy ... See more keywords
DARS-AS1 recruits METTL3/METTL14 to bind and enhance DARS mRNA m6A modification and translation for cytoprotective autophagy in cervical cancer
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DOI: 10.1080/15476286.2022.2079889
Abstract: ABSTRACT Cervical cancer (CC) is one of the most prevalent malignancies among females. Cytoprotective autophagy could confer cancer cell tolerance to hypoxic stress, promoting cell survival and adaptation. Aspartyl-tRNA synthetase 1 antisense 1 (DARS-AS1) is… read more here.
Keywords: dars as1; cytoprotective autophagy; cervical cancer; dars mrna ... See more keywords
Inhibiting Cytoprotective Autophagy in Cancer Therapy: An Update on Pharmacological Small-Molecule Compounds
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DOI: 10.3389/fphar.2022.966012
Abstract: Autophagy is a self-degradation process in which damaged proteins and organelles are engulfed into autophagosomes for digestion and eventually recycled for cellular metabolism to maintain intracellular homeostasis. Accumulating studies have reported that autophagy has the… read more here.
Keywords: small molecule; cytoprotective autophagy; molecule compounds; cancer ... See more keywords