Urgent cytoreduction for newly diagnosed acute myeloid leukemia patients allows acquisition of pretreatment genomic data and enrollment on investigational clinical trials
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Hematology"
DOI: 10.1002/ajh.26572
Abstract: Newly diagnosed acute myeloid leukemia is often deemed a medical emergency, requiring urgent treatment. This is in contradiction with the need for accurate cytogenetic and molecular data, which is not immediately available, to select optimal… read more here.
Keywords: cytoreduction; myeloid leukemia; newly diagnosed; group ... See more keywords
Pre‐transplantation cytoreduction does not benefit advanced myelodysplastic syndrome patients after myeloablative transplantation with grafts from family donors
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Communications"
DOI: 10.1002/cac2.12140
Abstract: The role of pre‐hematopoietic stem cell transplantation (HSCT) cytoreduction with either induction chemotherapy (IC) or hypomethylating agents (HMAs) in treating advanced myelodysplastic syndrome (MDS) remains debatable. We aimed to evaluate pre‐HSCT strategies by comparing the… read more here.
Keywords: advanced myelodysplastic; pre transplantation; myelodysplastic syndrome; transplantation ... See more keywords
Invited commentary: Author's response to “CRS and HIPEC: Best model of antifragility in surgical oncology”
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Surgical Oncology"
DOI: 10.1002/jso.26904
Abstract: I appreciate the commentary from Souadka et al. regarding our manuscript evaluating the potential benefit of hyperthermic intraperitoneal chemotherapy (HIPEC) for cases of incomplete cytoredu-cion. 1 Addressing the questions raised in the commentary the first… read more here.
Keywords: oncology; cytoreduction; surgical oncology; crs ... See more keywords
Chemotherapy in pancreatic ductal adenocarcinoma: When cytoreduction is the aim. A systematic review and meta-analysis.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer treatment reviews"
DOI: 10.1016/j.ctrv.2022.102338
Abstract: BACKGROUND In pancreatic ductal adenocarcinoma cytoreduction can be curative, or palliative. FOLFIRINOX and GEM-NAB are the two FDA/EMA approved regimens for advanced disease. We aim to identified the most cytoreductive regimen on the basis of… read more here.
Keywords: meta analysis; gem nab; cytoreduction;
Aggressive Surgical Approach to the Management of Neuroendocrine Tumors: A Report of 1,000 Surgical Cytoreductions by a Single Institution.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American College of Surgeons"
DOI: 10.1016/j.jamcollsurg.2016.12.032
Abstract: BACKGROUND Neuroendocrine tumors (NETs) are rare neoplasms. Our group has treated more than 2,000 NET patients and has performed more than 1,000 surgical cytoreductive procedures. STUDY DESIGN Records of 834 NET patients who underwent surgical… read more here.
Keywords: small bowel; institution; 000 surgical; neuroendocrine tumors ... See more keywords
Intraperitoneal hyperthermic chemotherapy after cytoreduction in patients with peritoneal metastases from endometrial cancer. The next frontier?
Sign Up to like & getrecommendations! Published in 2020 at "Surgical oncology"
DOI: 10.1016/j.suronc.2019.12.002
Abstract: BACKGROUND Endometrial cancer is the most common malignancy of the female genital tract. For cancers detected at an advanced stage or intraperitoneal relapse, the prognosis is poor. Optimal cytoreductive surgery (CRS) is the most accepted… read more here.
Keywords: chemotherapy; patients peritoneal; metastases endometrial; endometrial cancer ... See more keywords
Sarcopenia is associated with higher surgical complexity in patients undergoing interval cytoreduction for advanced epithelial ovarian carcinoma
Sign Up to like & getrecommendations! Published in 2021 at "Gynecologic Oncology"
DOI: 10.1016/s0090-8258(21)01165-3
Abstract: Objectives: Loss of skeletal muscle mass (sarcopenia) has been correlated with adverse postoperative outcomes after primary cytoreduction in patients with epithelial ovarian carcinoma (EOC). We investigated the association between sarcopenia as measured by skeletal muscle… read more here.
Keywords: sarcopenia; epithelial ovarian; patients undergoing; cytoreduction ... See more keywords
Response to Re: ‘Neoadjuvant chemotherapy for advanced ovarian cancer. Who really benefits?’
Sign Up to like & getrecommendations! Published in 2018 at "Australian and New Zealand Journal of Obstetrics and Gynaecology"
DOI: 10.1111/ajo.12925
Abstract: completed SCORPION study comparing NAC to primary surgery, clearly demonstrated that patient symptoms and quality of life were significantly better in the neoadjuvant chemotherapy arm.2 The author also suggests that the low optimal primary cytoreduction… read more here.
Keywords: chemotherapy; surgery; ovarian cancer; neoadjuvant chemotherapy ... See more keywords
Secondary surgical cytoreduction needs to be assessed taking into account surgical technique, completeness of cytoreduction, and extent of disease
Sign Up to like & getrecommendations! Published in 2020 at "World Journal of Surgical Oncology"
DOI: 10.1186/s12957-020-01853-4
Abstract: Recent evidence suggested that secondary surgical cytoreduction followed by chemotherapy does not result in longer overall survival in patients with platinum-sensitive recurrent ovarian cancer. This statement is based on a phase III multicenter, randomized clinical… read more here.
Keywords: disease; surgical cytoreduction; cytoreduction; surgical technique ... See more keywords
Preoperative serum levels of HE4 and CA125 predict primary optimal cytoreduction in advanced epithelial ovarian cancer: a preliminary model study
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Ovarian Research"
DOI: 10.1186/s13048-020-0614-1
Abstract: Objective The aim of this study is to establish a noninvasive preoperative model for predicting primary optimal cytoreduction in advanced epithelial ovarian cancer by HE4 and CA125 combined with clinicopathological parameters. Methods Clinical data including… read more here.
Keywords: primary optimal; preoperative serum; advanced epithelial; model ... See more keywords
The role of CA-125, GLS and FASN in predicting cytoreduction for epithelial ovarian cancers
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DOI: 10.1186/s13104-020-05188-x
Abstract: Cytoreduction has an important role in improving the survival rate of epithelial ovarian cancer (EOC) patients. This study aimed to assess the ability of preoperative serum CA125, FASN and GLS as predictors of cytoreductive surgery… read more here.
Keywords: gls; epithelial ovarian; 125 gls; cytoreduction ... See more keywords