Electrooxidation of cytosine on bare screen-printed carbon electrodes studied by online electrochemistry-capillary electrophoresis-mass spectrometry
Sign Up to like & getrecommendations! Published in 2019 at "Electrochemistry Communications"
DOI: 10.1016/j.elecom.2018.12.017
Abstract: Abstract The electrooxidation of cytosine on common commercially available screen-printed carbon electrodes was investigated. To characterize the processes on the electrode surface, the oxidation products were analyzed by online electrochemistry-capillary electrophoresis-mass spectrometry. Capillary electrophoresis was… read more here.
Keywords: printed carbon; capillary electrophoresis; electrochemistry; cytosine ... See more keywords
Application of TMAH thermochemolysis to the detection of nucleobases: Application to the MOMA and SAM space experiment.
Sign Up to like & getrecommendations! Published in 2019 at "Talanta"
DOI: 10.1016/j.talanta.2019.06.076
Abstract: Thermochemolysis of seven nucleobases-adenine, thymine, uracil, cytosine, guanine, xanthine, and hypoxanthine-in tetramethylammonium hydroxide (TMAH) was studied individually by pyrolysis gas chromatography mass spectrometry in the frame of the Mars surface exploration. The analyses were performed… read more here.
Keywords: application; tmah; cytosine; thermochemolysis ... See more keywords
Small Molecule Modulation of APOBEC3A-Catalyzed Cytosine Deamination in CCG Repeat Deoxyribonucleic Acid via Stabilization of Hairpin Structures.
Sign Up to like & getrecommendations! Published in 2025 at "Biochemistry"
DOI: 10.1021/acs.biochem.5c00501
Abstract: Repeat expansions in the genome are associated with numerous genetic diseases. The instability of repeat sequences is driven in part by slipped-out structures, such as hairpins. APOBEC3A (A3A), a cytosine deaminase, preferentially targets single-stranded DNA,… read more here.
Keywords: repeat; hairpin structures; deamination; ccg ... See more keywords
Photoreactive Cytosine-Functionalized Self-Assembled Micelles with Enhanced Cellular Uptake Capability for Efficient Cancer Chemotherapy.
Sign Up to like & getrecommendations! Published in 2021 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.1c01199
Abstract: Design, fabrication, and control of photoreactive supramolecular macromers─which are composed of a thermoresponsive polymer backbone and photoreactive nucleobase end-groups─to achieve the desired physical-chemical performance and provide the high efficiency required for chemotherapy drug delivery purposes… read more here.
Keywords: photoreactive cytosine; drug delivery; drug; cytosine functionalized ... See more keywords
How Human TET2 Enzyme Catalyzes the Oxidation of Unnatural Cytosine Modifications in Double-Stranded DNA.
Sign Up to like & getrecommendations! Published in 2022 at "ACS catalysis"
DOI: 10.1021/acscatal.2c00024
Abstract: Methylation of cytosine bases is strongly linked to gene expression, imprinting, aging, and carcinogenesis. The Ten-eleven translocation (TET) family of enzymes, which are Fe(II)/2-oxoglutarate (2OG)-dependent enzymes, employ Fe(IV)=O species to dealkylate the lesioned bases to… read more here.
Keywords: tet2 enzyme; oxidation unnatural; cytosine; double stranded ... See more keywords
iPS cell generation-associated point mutations include many C > T substitutions via different cytosine modification mechanisms
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-49335-5
Abstract: Genomic aberrations are a critical impediment for the safe medical use of iPSCs and their origin and developmental mechanisms remain unknown. Here we find through WGS analysis of human and mouse iPSC lines that genomic… read more here.
Keywords: generation; point mutations; mutations observed; ips cell ... See more keywords
2-Guanidyl pyridine PNA nucleobase for triple-helical Hoogsteen recognition of cytosine in double-stranded RNA.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc02615e
Abstract: In triplex-forming peptide nucleic acid, a novel 2-guanidyl pyridine nucleobase (V) enables recognition of up to two cytosine interruptions in polypurine tracts of dsRNA by engaging the entire Hoogsteen face of C-G base pair. Ab… read more here.
Keywords: recognition; cytosine; pyridine pna; pna nucleobase ... See more keywords
Self-healing polyacrylamide (PAAm) gels at room temperature based on complementary guanine and cytosine base pairs.
Sign Up to like & getrecommendations! Published in 2022 at "Soft matter"
DOI: 10.1039/d2sm00933a
Abstract: The unique properties of self-healing materials hold great potential in many fields because they can repair themselves automatically and have an improved service time. In this study, polyacrylamide (PAAm) gels with complementary guanine and cytosine… read more here.
Keywords: self healing; cytosine; paam gels; temperature ... See more keywords
Selective and Catalytic Conversion of Hydroxymethyl Cytosine to Formyl Cytosine by a Synthetic Model of TET Enzymes
Sign Up to like & getrecommendations! Published in 2024 at "Inorganic Chemistry Frontiers"
DOI: 10.1039/d4qi01965b
Abstract: The TET enzymes, known as the ten-eleven translocation enzymes, have become central figures in epigenetic regulation due to their remarkable ability to oxidize 5-methylcytosine (5-mC) to 5-hydroxymethylcytosine (5-hmC), 5-formylcytosine (5-fC),... read more here.
Keywords: selective catalytic; catalytic conversion; tet enzymes; conversion hydroxymethyl ... See more keywords
ImmuMethy, a database of DNA methylation plasticity at a single cytosine resolution in human blood and immune cells.
Sign Up to like & getrecommendations! Published in 2022 at "Database : the journal of biological databases and curation"
DOI: 10.1093/database/baac020
Abstract: Differential DNA methylation is a feature of numerous physiological and pathological processes. However, the extent to which single-base cytosine methylation modifies cellular responses to various stimuli has not been well characterized. In this study, we… read more here.
Keywords: cytosine; dna methylation; immumethy database; methylation ... See more keywords
Cytosine base modifications regulate DNA duplex stability and metabolism.
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic acids research"
DOI: 10.1093/nar/gkab509
Abstract: DNA base modifications diversify the genome and are essential players in development. Yet, their influence on DNA physical properties and the ensuing effects on genome metabolism are poorly understood. Here, we focus on the interplay… read more here.
Keywords: stability; dna; metabolism; base modifications ... See more keywords